Journal of Proteomics & Bioinformatics

Journal of Proteomics & Bioinformatics
Open Access

ISSN: 0974-276X

+44 1223 790975

Christopher Linden

Christopher Linden

United Kingdom

  • Review Article
    Developments in Cardiovascular Proteomics
    Author(s): Melissa A Noronha, Christopher Linden and Parveen SharmaMelissa A Noronha, Christopher Linden and Parveen Sharma

    Cardiovascular diseases (CVD) are the leading cause of mortality and morbidity worldwide. These diseases can occur rapidly as seen in acute myocardial infarction or develop over a number of years as seen in chronic heart failure. The use of a number of drugs for chronic conditions in our aging population is compounding existing rates of CVDs due to cardiotoxicity. Recent advances in proteomics coupled with innovative separation and isolation techniques of subproteomes have vastly improved our knowledge of the cardiac proteome. Mass spectrometry imaging (MSI) is further providing information on spatial distribution of proteins and drugs. Here, we evaluate current advances in separation and detection of proteins, drugs and active metabolites being used to gain insights into mechanisms and diagnostic markers. Taken together these innovative techniques provide the necessary tools to inves.. View More»
    DOI: 10.4172/jpb.1000400

    Abstract PDF

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