Journal of Proteomics & Bioinformatics
Open Access

Brian Cox

Publications

• Review Article
  Proteomics Analysis of Preeclampsia, a Systematic Review of Maternal and Fetal Compartments
  Author(s): Frances Wong and Brian CoxFrances Wong and Brian Cox
  
  Preeclampsia is a relatively common hypertensive disorder of pregnancy that remains a high cause of maternal and fetal death due to the lack of early detection and treatment options. While the etiology is unclear, the placenta is the origin of preeclampsia and it releases factors into maternal circulation to induce systemic endothelial dysfunction. Preeclampsia is a heterogeneous condition and a single biomarker is likely incapable of identifying all women at risk of developing the condition. Proteomic efforts have been largely directed to analysis of maternal blood serum or the placental tissue. Altered protein expression in the placenta suggests a role in the development of preeclampsia while altered protein expression in maternal serum indicates factors secreted from the placenta or maternal responses to these factors. In this systemic review, 12 studies comparing samples f.. View More»
  DOI: 10.4172/jpb.S10-001

  Abstract PDF

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