ISSN: 0974-276X
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Borna H
West Indies
Research Article
Mechanistical Approach Through Discovery of New Generations of Anti Inflammatory Drugs
Author(s): Hashemi M, Borna H, Dadras O, Shafaroodi H, Akbarzade A and Hajiali SHashemi M, Borna H, Dadras O, Shafaroodi H, Akbarzade A and Hajiali S
Non-Steroid-Anti-Inflammatory-Drugs (NSAIDs) are the main focal points of linkage between inflammation and cancer. These compounds affect the catalytic conversion of Arachidonic Acid to the main molecules of prostaglandin family. These exchanges are catalyzed by CycloOxygenase isozymes called COX I & II which are constitutive proteins in important organs like liver or kidney and inducible one in inflamed tissues or tumors, respectively. This study discusses on a new mechanistic approach through discovery of 4th generation of NSAIDs. Here utilizing combinations of online databases including DRUG BANK and PUBCHEM in conjunction with computational algorithms like Fast Flexible Docking as in FLEXX software followed by applying new filtering processes including extraction of structural descriptors by means of PASS software. Also, correlation between docking scores and bioactivities wer.. View More»
DOI:
10.4172/jpb.1000202