Journal of Proteomics & Bioinformatics

Journal of Proteomics & Bioinformatics
Open Access

ISSN: 0974-276X

+44 1223 790975

Archunan G

Publications
  • Research Article
    Characterization of Rat Odorant Binding Protein Variants and its Post-Translational Modifications (PTMs): LC-MS/MS analyses of Protein Eluted from 2D-Polyacrylamide Gel Electrophoresis
    Author(s): Rajkumar R, Ilayaraja R, Alagendran S, Archunan G, Muralidharan A.R, Huang P. H, Ng WV and Chen-Chung LiaoRajkumar R, Ilayaraja R, Alagendran S, Archunan G, Muralidharan A.R, Huang P. H, Ng WV and Chen-Chung Liao

    Identification of odorant-binding protein (OBP) variants in mammalian system is of great importance to an understanding of their role in the binding of pheromones and other volatiles during chemical communication. Our previous proteomics studies have revealed the presence of OBP as well as confirming that, in the preputial gland of Indian commensal rat, the bound form of the protein associates with various farnesols. In addition to this, a recent mass spectrometry based proteomics analysis has shown that rat recombinant OBP undergoes post-translational modification (PTM) and there are a number of different variants in terms of phosphorylation. This suggests that the phosphorylation of OBP may affect its binding properties and the binding properties may change in the presence of phosphorylation. Thus, in the present investigation we have investigated these OBP variants. The vari.. View More»
    DOI: 10.4172/jpb.1000191

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