Journal of Proteomics & Bioinformatics

Journal of Proteomics & Bioinformatics
Open Access

ISSN: 0974-276X

+44 1223 790975

Amanda Voros

  • Research Article
    The Secretome of Mycoplasma capricolum subsp. capricolum in Neutral and Acidic Media
    Author(s): Amanda Voros, Johanna DeLongchamp and Mazen SalehAmanda Voros, Johanna DeLongchamp and Mazen Saleh

    Mycoplasmas have proven to be successful pathogens despite their minimal genomes in some species. Their simplistic nature makes them an important tool for understanding the genes involved in basic metabolic processes and pathogenesis. Of particular interest are the genes involved in mycoplasma evasion of host immune responses and survival within phagocytic cells. The proteins secreted by mycoplasmas in the acidic and hydrolytic environment of a macrophage may help to uncover important virulence factors of this group of prokaryotes. This study examined the effect of pH on the secretome of Mycoplasma capricolum. The bacterium was cultured in protein-free media and the culture supernatant was investigated for proteins produced during growth. Twodimensional gel electrophoresis followed by MALDI-TOF mass spectrometry of tryptic digests was used to identify the proteins in this frac.. View More»
    DOI: 10.4172/jpb.1000364

    Abstract PDF

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