Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
+44 1223 790975
ISSN: 0974-276X
+44 1223 790975
Allan R Brasier
Sealy Center for Molecular Medicine,
Galveston, TX
Tanzania
Research Article
Diagnostics for Statistical Variable Selection Methods for Prediction of
Peptic Ulcer Disease in Helicobacter pylori Infection
Author(s): Hyunsu Ju, Allan R Brasier, Alexander Kurosky, Bo Xu, Victor E Reyes and David Y GrahamHyunsu Ju, Allan R Brasier, Alexander Kurosky, Bo Xu, Victor E Reyes and David Y Graham
Background: The development of accurate classification models depends upon the methods used to identify the most relevant variables. The aim of this article is to evaluate variable selection methods to identify important variables in predicting a binary response using nonlinear statistical models. Our goals in model selection include producing non-overfitting stable models that are interpretable, that generate accurate predictions and have minimum bias. This work was motivated by data on clinical and laboratory features of Helicobacter pylori infections obtained from 60 individuals enrolled in a prospective observational study. Results: We carried out a comprehensive performance comparison of several nonlinear classification models over the H. pylori data set. We compared variable selection results by Multivariate Adaptive Regression Splines (MARS), Logistic Regression with regulariza.. View More»
DOI:
10.4172/jpb.1000308