Journal of Proteomics & Bioinformatics
Open Access

Alistair VG Edwards

Publications

• Short Communication
  ReportSites - A Computational Method to Extract Positional and Physico-Chemical Information from Large-Scale Proteomic Post-Translational Modification Datasets
  Author(s): Alistair VG Edwards, Gregory J Edwards, Martin R Larsen and Stuart J CordwellAlistair VG Edwards, Gregory J Edwards, Martin R Larsen and Stuart J Cordwell
  
  Background: Extracting biological meaning from proteomic datasets containing post-translational modification is a central challenge of large scale proteomics and systems biology. We report the generation of a new program (ReportSites) to precisely identify the location and local chemical environment of a particular amino acid residue, or group of residues, within large-scale proteomic data sets, using peptide sequences characterized by mass spectrometry combined with protein sequence databases. The program is ideally suited to distilling regional and spatial information from post-translational modification data sets, wherein patterns of sequence surrounding processed sites may reveal more about the functional and structural requirements of the modification and the biochemical processes that regulate them. Results: We developed ReportSites usin.. View More»
  DOI: 10.4172/jpb.1000220

  Abstract PDF

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