Alexander E Berezin
State Medical University,
26, Mayakovsky av., Zaporozhye
Immune Phenotypes of Endothelial-Derived Microparticles in Dysmetabolic Patients.
Author(s): Alexander E Berezin, Alexander A Kremzer, Tatyana A Samura, Tatyana A Berezina and Peter KruzliakAlexander E Berezin, Alexander A Kremzer, Tatyana A Samura, Tatyana A Berezina and Peter Kruzliak
Type two diabetes mellitus remains a leading contributor to cardiovascular mortality worldwide. This study was conducted to investigate the pattern of circulating endothelial-derived microparticles in diabetes patients in comparison with metabolic syndrome subjects. Methods: The study retrospectively evolved 101 patients (54 subjects with type two diabetes mellitus and 47 patients with metabolic syndrome) and 35 healthy volunteers. All the patients have given written informed consent for participation in the study. Biomarkers were measured at baseline of the study. Results: There is a significant difference between healthy subjects and patients regarding CD31+/annexin V+ to CD62E+ ratio of endothelial-derived microparticle, which reflects impaired phenotype of microparticles. Therefore, CD31+/annexin V+ to CD62E+ ratio was found to be higher in the type two diabete.. Read More»