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Journal of Proteomics & Bioinformatics

Journal of Proteomics & Bioinformatics
Open Access

ISSN: 0974-276X

Abdelouahab Chikhi

Abdelouahab Chikhi

Constantine
Algeria

Publications
  • Research Article
    In Silico Study of the Selective Inhibition of Bacterial Peptide Deformylases by Several Drugs
    Author(s): Abdelouahab Chikhi and Abderrahmane BensegueniAbdelouahab Chikhi and Abderrahmane Bensegueni

    To counter increasing levels of pathogen resistance new classes of antibiotics are needed without delay. The metalloenzyme peptide deformylase (PDF) correspond to one of the most promising bacterial targets in the search for novel mode of antibiotics action and was firstly selected as a specific bacterial target. Peptide analogs were developed as inhibitors containing a hydroxamate or formyl- hydroxylamine as metal interacting group, and used as inhibitors with in vitro activity against a broad spectrum of organisms and successful antibacterial activity in vivo that is harmonizing with good pharmacokinetic properties and excellent tolerability in diverse species, but a human homologue was recently discovered. A new strategy for selecting highly efficient compounds with low inhibition effect against human PDF was developed. An original class of small, non-peptidic inhi.. Read More»
    DOI: 10.4172/jpb.1000122

    Abstract PDF

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