Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Abbas Farazmand
Iranian Research Organization for Science and Technology (IROST),
15815- 3538, Tehran
West Indies
Research Article
Bacillus clausii and Bacillus halodurans lack GlnR but Possess Two Paralogs of glnA
Author(s): Abbas Farazmand, Bagher Yakhchali, Parvin Shariati and Hamideh OfoghiAbbas Farazmand, Bagher Yakhchali, Parvin Shariati and Hamideh Ofoghi
Bacillus clausii and Bacillus halodurans lack GlnR but possess a single TnrA regulator of nitrogen assimilation and two paralogs of glnA. Bacillus clausii contains two paralogs of the gene encoding the glutamine synthetase (GS), glnA1 (ABC3940) and glnA2 (ABC2179). The glnA1 gene contains a TnrA site. This TnrA site is located downstream of the -10 region of the promoter. However, the glnA2 gene does not contain the TnrA site at its regulatory region. Bacillus haloduranspossesses two paralogs of glnA, both with TnrA-binding sites. The glnA1 (BH2360) gene contains a TnrA site, which overlaps the -10 region of the glnA1 promoter, and the glnA2 (BH3867) gene contains a TnrA site downstream of the -10 region of its promoter. Also, the Bacillus subtilis dicistronic glnRA operon, which encodes GlnR and GS, contains two TnrA sites (glnRAo1 and glnRAo2) in its promoter region. The glnRAo2 sit.. View More»
DOI:
10.4172/jpb.1000187