This review addresses the effect of ingested toxins, malnutrition, stress, infection, and electromagnetic pollution in development of diseases. Some toxins are transmitted by umbilical cordon blood in birth and others are ingested by orally as monosodium glutamate, fructose, soft drinks, gluten, oils, xenoestrogens and heavy metals. Consequently, these toxins if accumulate in the body and overloading the liver, favoring only diseases. Lack of basic nutrients as water, magnesium, iodine, stomach acid, amino acids and fatty acids were strongly linked with achlorhydria, growth of diabetes and cardiovascular disease. Dental infection destroys mitochondria’s through of gliotoxins, mercury, thioesters and oral infections can cause many systemic diseases. Root canals contain a significant source of bacteria and fungi in the circulation blood and endodontic treatment can be the cause of anaerobic bacteremia and fungemia predisposing the chronic disease. Sleep deprivation and to sleep with light on, tablets, cell phone next to bed commits the release of melatonin by pineal gland. Electromagnetic pollution contribute for headaches, depression, anxiety, palpitation and these symptoms are linked with electrical hypersensitivity that have been associated with diabetes, multiple sclerosis and attention deficit hyperactivity disorders. Thereby, we believe that is need paradigm change in the medical model for investigate these factors in your patients because currently this is not being done.