Toxins, Malnutrition, Stress, Infections and Electromagnetic Poll
Journal of Nutrition & Food Sciences

Journal of Nutrition & Food Sciences
Open Access

ISSN: 2155-9600

Review Article - (2016) Volume 6, Issue 6

Toxins, Malnutrition, Stress, Infections and Electromagnetic Pollution: Looking about New Perspectives in Development of Diseases

Peres HA1*, Pereira LRL2 and Foss MCF1
1Department of Internal Medicine, Ribeirão Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil, E-mail:
2Department of Pharmaceutical Sciences, University of Sao Paulo, Ribeirão Preto, Sao Paulo, Brazil, E-mail:
*Corresponding Author: Peres HA, Department of Internal Medicine, Ribeirão Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil, Tel: +55 11 3091-3116


This review addresses the effect of ingested toxins, malnutrition, stress, infection, and electromagnetic pollution in development of diseases. Some toxins are transmitted by umbilical cordon blood in birth and others are ingested by orally as monosodium glutamate, fructose, soft drinks, gluten, oils, xenoestrogens and heavy metals. Consequently, these toxins if accumulate in the body and overloading the liver, favoring only diseases. Lack of basic nutrients as water, magnesium, iodine, stomach acid, amino acids and fatty acids were strongly linked with achlorhydria, growth of diabetes and cardiovascular disease. Dental infection destroys mitochondria’s through of gliotoxins, mercury, thioesters and oral infections can cause many systemic diseases. Root canals contain a significant source of bacteria and fungi in the circulation blood and endodontic treatment can be the cause of anaerobic bacteremia and fungemia predisposing the chronic disease. Sleep deprivation and to sleep with light on, tablets, cell phone next to bed commits the release of melatonin by pineal gland. Electromagnetic pollution contribute for headaches, depression, anxiety, palpitation and these symptoms are linked with electrical hypersensitivity that have been associated with diabetes, multiple sclerosis and attention deficit hyperactivity disorders. Thereby, we believe that is need paradigm change in the medical model for investigate these factors in your patients because currently this is not being done.

Keywords: Toxins; Malnutrition; Stress; Infections; Electromagnetic pollution


Nowadays, why do some people get sick and others not? Worldwide, the people live connected the internet, drinking more beer and sugar-sweetened beverage that water, consuming more processed foods compared the ancestors, do not sleep needed and taking drugs for control some diseases. Hippocrates, father of medicine, 431 B.C. said: Let food be thy medicine and medicine be thy food, however, currently we do drugs our food and drugs are foreign substances for human body containing adverse effects. Unfortunately, current medical model is based in suppression of symptoms thereby, are prescribed more drugs for treatment of symptoms. On the other hand, the conceit of prevention of diseases and like having health is little taught in majority medical schools worldwide, and this form, the physicians become experts only in diseases treatment.

When compared Neolithic Era with lifestyle current is noteworthy the differences in the type of food, time of sun exposure, hours of sleep, physical activity (Table 1). We consumed more calories daily compared decade of 1980 modifying the leptin, hormones satiety [1,2].

Neolithic period Worldwide
Organic foods Processed foods
Good sleep quality Poor sleep quality
High sunlight's (more vitamin D) Low Sunlight's (less vitamin D)
Low sanitation High sanitation
High physical activity Low physical activity
Higher breastfeeding Lower breastfeeding
Normal Birth Cesarean
Without artificial lights and telephone With artificial lights and telephone
Active lifestyle Sedentary lifestyle
High intake of fruits and vegetables Low intake of fruits and vegetables
Absence of fast food consumption Increase of fast food consumption
Low sugar intake High sugar intake
Little consumption of antibiotics Indiscriminate use of antibiotics
Low sodium diet High sodium diet
Soil rich in minerals(potassium and magnesium) Soil poor in minerals
Low consumption of alcoholic beverage High consumption of alcoholic beverage
Low consumption cigarette smoking High consumption cigarette smoking
Low gluten diet High gluten diet
Absence dairy, sausages and juices High dairy consumption, sausages and juices
High water intake Low water intake

Table 1: Differences of food between Neolithic period and worldwide.

Therefore, is crucial clarify the factors that impart resilience or contribute development some diseases that may arise through of toxins, malnutrition, infections, stress and electromagnetic pollution (Figure 1). Thereby, is objective this narrative review explain role these factors in diseases source and suggest alternative measures for prevention and illness treatment.


Figure 1: Ingested of toxins, more the malnutrition, stress, infections and electromagnetic pollution can contribute in development of diseases.


We eat what not should eat and thus overload the liver that is responsible for cleaning of toxins consumed as sugar, some sweeteners and oils for cooking, soft drinks and fructose (Figure 2). Toxins have presents in air, soil, water and some can be in the foods. However, some toxins can be transmitted umbilical cordon blood of according with Environmental Working Group (EWG). This study, the researchers found an average 200 industrial chemicals and pollutants in umbilical cord blood from 10 babies born in August and September 2004. After cord was cut, umbilical cord blood harbored pesticides, gasoline, consumer product ingredients, garbage and waster from burning coal [3]. High intake of sugar in pregnancy is great problem for newborns. Results of study HAPO (Hyperglycemia and Adverse Pregnancy Outcomes); found that of higher levels maternal glucose were associated with birth weight and an increased in the levels C-peptide in the cord-blood [4].


Figure 2: Exhibition to xenoestrogens and heavy metals added high consumption of fructose, monosodium glutamate, gluten and some cooking oils can contribute in development of chronic diseases.

Pesticides are considered essential for development of agriculture in worldwide, moreover the high levels of pesticides accepted for some countries like Brazil, become a great problem of health public [5]. Furthermore, they kill the funds and decreased the production of humic acid and fulvic acid which are crucial in the formation of feedstock for soil. Atrazine is the one of the most widely used herbicides in the Unites State in cultivation and have been associated with complications in female reproduction [6,7] and toxicity on human liver [8]. Heated Foodstuffs are dangerous for health. Besides, is noteworthy that French fries are strongly consumed for children’s, teens and adults the entire world, but when the potato is heated, she becomes in acrylamide, a carcinogen compound that may build-up in body human [9]. Thereby, there is a toxic overload in liver, kidneys, gut, pancreas and immune dysregulation contributing for appearance of diseases [10].

Monosodium glutamate (MSG) is the sodium salt of glutamic acid used in the food industry as flavor enhancer that intensifies for meaty, stews and meat soups that may increase sensibility for the flavor umami. MSG produces a salty flavor when added to food, thus excites your taste buds umami stimulating the release of brain neurotransmitters as glutamate. Glutamate is a neurotransmitter excitatory essential role for learning and memory it being, crucial for body in the produce of GABA (gamma-aminibutyric acid), which is a calming and inhibitory brain chemical. However, high intake of processed foods with MSG may make body lose the ability to convert glutamate into GABA, leading the build-up of glutamate with deficiency of GABA. Therefore, these dates has been linked to serious disorders, like: Obesity and Metabolic Syndrome [11,12], Autism [13] and Alzheimer’s disease [14].

Artificial sweeteners are consumed frequently for people trying to lose weight including obese children, patients with Diabetes and some sweeteners can have negative effects. A study done in 2014 found that consumption of artificial sweeteners it is associated with development of glucose intolerance through of induction of compositional and functional alterations to the intestinal microbiota in mice [15]. Aspartame is artificial sweeteners composed of methanol (10%) phenyalanine (50%) and aspartic acid (40%). After, human body convert methanol in formate, it can be excreted or can give rise to formaldehyde and a number of other highly toxic derivatives as the diketopiperazine, a carcinogen [16]. In a review done in 2008 researches reported that aspartame altered amino acid metabolism, integrity of nucleic acids, neuronal function, and balance endocrine and brain concentration catecholamines [17]. Furthermore, previously studies suggested an association between Aspartame consumption and risk of type 2 Diabetes [18] and preterm delivery [19].

Fructose is a kenotic monosaccharide sweeter that glucose or sucrose. Your absorption, digestion, metabolism differs from those of glucose. Unlike glucose, she does not stimulate insulin secretion or enhance leptin productions that control the food intake and body weight. Thus the high fructose consumption may contribute to increase energy intake and obesity [20]. There was an increase significantly of intake fructose of 1970 to 2000 and a 25% increase in added sugars this period [21]. In the pre-industrialization, the average consumption was day 15 g/fructose day and we obtained fructose through fresh fruits, vegetables and honey. However, with the inclusion of high-fructose corn syrup (HFCS), a sweetener made from corn starch more cheap that white sugar and done for replacing table sugar in food, made with that fructose intake increased 37 g/day and currently average consumed is 72.8/day [22]. Consequently, there was an increase of diseases as metabolic syndrome [23], diabetes [24], hypertriglyceridemia [25], nonalcoholic fatty liver disease [26] and cardio metabolic diseases due to high intake of HFCS. We increased sugar and fructose intake in the foods producing a new disease for society, the diabesity [27].

The soft drinks intake has been linked the type 2 diabetes [28,29], risk of gout [30], obesity and metabolic syndrome [31], deleterious effects on bone health [32] and coronary artery calcification [33]. Beyond sodium, some soft drinks containing caffeine which has diuretic effect, this form, how much more caffeine and sodium have in soft drink, more thirst the people will have, consuming more. A can of soda contains an average 150 cal, multiplied by 365 days (1 year) and divided by 3500 cal equivalent to about 500 g of weight, because for every 3,500 eaten and unburned calories, you gain about 500 g of weight [34]. Thereby, is noteworthy that over time the size of can of soda increased, thus there was an increasing in amount of calories, linked with weight gain of according to the Table 2. Interestingly, controlled trial done in schools with obese children found that the obesity decreases when the withdrew soda vending machine. In contrast, the obesity continues the increased in the schools with the soda vending machine [35].

Year/Amount Calories Days Calor X Days Overal/3500 Cal Weight/Year
1915...192 mL 82,28 365 30032 8,58 4,29
1955...300 mL 128 365 46720 13,35 6,67
1960...350 mL 150 365 54750 15,64 7,82
1990...590 mL 252,85 365 92290 26,37 13,18
1991...1000 mL 428,57 365 156428 44,69 22,35
1992...2000 mL 857,14 365 312856 89,39 44,69

Table 2: Amount of soda and weight gain.

Xenoestrogens are a sub-category of the endocrine disruptor group that imitates the actions of estrogens such Polychlorinated biphenyls (PCBs), bisphenol A (BPA), phthalates and are widely used industrial compounds producing adverse effects in human body. Bisphenol A is food contaminant utilized in fabrication of plastics, internal coating cans and it is found in bottles of plastic, plastic containers to store food, drinks and canned foods and children’s glass. However, human exposure to BPA could favor obesity [36], metabolic disorders such as hepatic steatosis [37], insulin resistance in childhood obesity [38], and autism spectrum disorder [39]. Recently, phthalates were associated with birth size and gestational that varied by sex and timing of exposure [40], and yet may affect serum thyroid hormones activity in newborns in period neurodevelopment [41].

Heavy metals chemical are elements constituents of the earth crust, however, high levels these compounds can lead the bioaccumulation in the human body and poisoning. These toxins can be introduced into the human body through beverages, foods, skin exposure and the inhaled air it is impossible to live in an environment free of heavy metals. That way, they change the function in glands and organs as enzymes, liver, bone, kidney, brain and heart. Lead can inactive the action of calcium, zinc, iron and when added to arsenic, cadmus and mercury produce synergism, increasing your toxicity. Besides that, they displace the vital nutritional minerals from their original place changing your biological function. On the other hand, as trace elements some metals as zinc, iron, cobalt, copper, selenium, and manganese are essentials for human body [42].

Lard or butter pig is composed of triglycerides obtained from any part of the pig where there is a high proportion of adipose tissue and was used in the past for people to cook. However, she was replaced by vegetables shortening (Crisco) from of 1911, with the strong advertising of be better than butter for you cooking and healthier. Vegetables oils are formed through an industrial process that adds hydrogen to vegetable shortening (partially hydrogenated), that it is cheaper to produce and required no refrigeration. So, the oil is solid at room temperature but melts at cooking temperature increasing shelf life of foods, thereby, there was the costs reduction and in a time when refrigerators were rare [43,44]. Interestingly, after of introduction vegetables oils, the consumption of soybean oil increased more a thousand fold and now supplies about 7% of calories in the U.S diet [45], besides of excess of Omega-6 that is harmful for health. Essential fatty acids as Omega-3 and Omega-6 are crucial for body because he can’t produce, must be obtained starting from the diet, but it must get them in a certain balance. In the past, the Omega-6: Omega-3 ratio was in around 4:1-1:2 and currently, the ratio is 16:1 on average with variation between individuals [46]. Added to this, vegetables oils contain large amount Omega-6 that have linked with inflammation [47], cardiovascular diseases [48], diabetes and obesity [49-51], asthma and eczema young children [52], cancer[53,54], homicides rate [55] and depression [56].

Gluten is a compound protein of gliadin and glutenin found in wheat, rye and barley. Gluten is found in biscuits, cakes, pasta, bread, breakfast cereals, flour, pizza bases, soups, sauces and sausages. He helps dough rise providing elasticity, strength and ability to hold food products together while maintaining a palatable texture [57]. In the past, the native diet of humans consisted of meats, fishes, vegetables and fruits with little exposure to grain, however, in the past 500 years the gluten content of foods increased significantly [58,59]. The gluten proteins may have a unique toxicity profile and distinct T-cell stimulatory sequences, as the gliadin, which cannot be degraded by intestinal enzymes and trigger an immune reaction in predisposed individuals. Therefore, the consumption elevated of gluten in modern diet have been linked the gluten-related-disordens as celiac disease and non-celiac gluten sensibility [60], wheat allergy [61], dermatitis herpetiformis [62], gluten ataxia [63], autism [64] and helicobacter pylori infection [65].


Malnutrition occurs when there a reduction of basic nutrients for human body as the water, vitamins, minerals, amino acids and fatty acids. Nowadays, our food is poor in vitamins and minerals because the famers plan only one type of vegetal or fruit in soil (monoculture) and fertilize the land with little nutrients, thus occur a soil nutrients depletion causing a deficiency these nutrients for the fruits or vegetables. The reduction these nutrients in diet represents the largest public health concern contributor for diseases development affecting quality of life of people in developing and developed countries [66]. Currently, more 805 million people worldwide are undernourished and so, the malnutrition leads to deficiencies of micronutrients as the iron, vitamin A, vitamin B12, folate and riboflavin that are linked the anaemia [67].

Some diseases have been associated with reduction of vitamins, minerals, amino acids and fatty acids. Vitamin D deficiency in general population is associated with increased cardiovascular risk [68], allergic diseases [69], death in the intensive care unit [70], musculoskeletal and autoimmune diseases [71,72] type 2 diabetes [73], obesity and cancer [74,75]. On the other hand, a systematic review found that supplementation with vitamin D3 decreased cancer mortality by 12% and vitamin D decreased all-cause mortality by 7% among adults [76].

Magnesium is the most common element in the crust of earth and is essential for human health, because it is involved in the homeostasis, protein synthesis and DNA stability [77]. However, there a deficiency of magnesium in general population in worldwide, that contributing for a number of chronic diseases such the migraine [78], epilepsy [79], depression [80], Alzheimer’s [81], cardiovascular diseases [82], hypertension [83] type 2 diabetes and insulin resistance [84,85], attention deficit hyperactivity syndrome [86-87] asthma [88] and preeclampsia [89].

Hydrocloridric acid (HCl) is produced by parietal cells of stomach in response to ingested protein or fat, however, when eats more than required by body and with the aging, acid production begins to decrease. In the body human, stomach pH is 1.5-3.0 and parietal cells need of iodine, zinc, water and thiamine for produce HCl, thereby, when taking H2 blockers or proton-pump inhibitors there an increase of pH stomach (>4.0) modifying the function of the digestives enzymes and pyloric valve that are pH dependent. Consequently, the low production of HCl decreased digesting food, amino acids, minerals and vitamins principally the vitamin B12 and folic acid, contributing for abnormal growth bacterial, intestinal dysbiose and immune system deficiency. Thus, favor the appearance of diseases like atrophic gastritis [90], gastro esophageal reflux [91], asthma [92] esophagus Barrett [93], achlorhydria [94] and increased intestinal permeability that can predispose the autoimmune diseases [95,96].

Iodine is an element crucial for all cell and glands of human body especially for the thyroid in production of hormones thyroid and the iodine deficiency is a global health issue, because the amount of iodine in soil is low and intake dietary in adults is <150 μg/day of according World Health Organization [97,98]. Low intake iodine, selenium, zinc and iron have been linked with type 2 hypothyroidism because the deiodinase enzyme no converted T4 to T3 [99,100]. Iodine deficiency in pregnancy have been associated with cretinism [101], impact neuropsychological development in school aged children [102], in adults iodine deficiency is linked with intestinal failure [103] increase cardiovascular disease risk in overweigh people [104], goiter with complications and impaired mental function [105].


Nowadays, people in worldwide are dying due to the antibioticresistant- bacteria (superbugs) and by infection diseases. Dental infections destroy mitochondria’s through of thioesters, gliotoxins and mercury and are the most common diseases in the oral and maxillofacial region. However, majority of chronic systemic disease are due to infection in the tonsils or teeth that are symptom-less and very difficult to detect. Oral infections as the periodontitis can cause the course number of systemic diseases such as cardiovascular disease, cerebrovascular disease, bacterial pneumonia, diabetes mellitus, osteoporosis and adverse pregnancy outcome [106-108]. Cells human body become oxidized by toxins that are pro-oxidant causing damage and altering their normal function and in advanced cancer patients, between two and ten dead teeth, always included root canal teeth. Various study found that all root canal teeth with symptomatic apical periodontitis contain anaerobic bacteria and are a significant source of bacteria and fungi in the circulation blood and endodontic treatment can be the cause of anaerobic bacteremia and fungemia and thereby predispose the various chronic diseases [109-112].


Currently, all living organism are challenged by internal or external adverse effects that change the homeostasis human body, defined like stress. Noteworthy that worldwide the stress in the people increased and no decreased because work, sedentary, food, sleep loss, socioeconomics and ideological factors, contributing by diseases as hypertension [113], diabetes [114], depression [115], some type of cancers [116], autoimmune diseases [117,118] and autism [119].

Sleep deprivation has been liked with various diseases in worldwide because nothing is healthier by human body that a good sleep night. In the past, we ancestral slept much earlier and totally in the dark, thus there was no failure in production of melatonin by pineal gland. In contrast, the current society sleeps with the light on, television on, tablets and cell phone next to bed. So there a failure of pineal gland in release of melatonin because the lighting of these devices stimulates serotonin production, tricking the pineal gland into thinking it’s daytime, confusing the wake/sleep cycle.

Electromagnetic Pollution

Electromagnetic pollution or electromagnetic radiation consists of the waves of energy combining electrical and magnetic fields classified in ionizing radiation and non-ionizing radiation based on its capability of ionizing atoms. Electromagnetic energy that flow along a conductor is a quality power poor also known as dirty energy. Dirty energy is ubiquitous and is generated by electronic equipment as computers, plasma television, energy efficient appliances, dimmer switches, cell phones and broadcast antennas. In buildings, the neighbors who share the same transformer produce dirty energy that contribute by symptoms of radio wave sickness as headaches, dizziness, memory loss, depression, anxiety, palpitations, arrhythmias, pain or pressure in the chest, low or high blood pressure and these symptoms are linked with electrical hypersensitivity [120,121]. Electrical hypersensitivity affect 3% of the population and 35% have your symptoms. Increase of diseases as diabetes, multiple sclerosis, attention deficit hyperactivity disorders, fibromyalgia and asthma chronic fatigue may be linked with electrical hypersensitivity, but reasons still are poorly understood [122]. A study done in laboratory found that insulin release and insulin binding capacity to receptors cell were reduced by electromagnetic fields [123,124]. Besides, it is know that blood sugar levels are increased by stress in diabetics that are exposed the electromagnetic energy induced the stress proteins at various frequencies [125,126]. More investigation this area are need for discovery the mechanisms involved and percentage of population affected.


Malfunction of pancreas, adrenals glands and thyroid that are organs unison is gateway by diseases. In the chronic diseases, the patients have type II hypothyroidism, deficiency of vitamins, minerals, fatty acids, low intake of fruits and vegetables, low physical activity and an excess of fat trans and sugar principally because industrialized food that make part diet in population worldwide. Besides, the toxins, heavy metals dental infection and electromagnetic pollution can contribute for complications in chronic diseases, thus all these factors are crucial for epidemics of chronic and Western diseases, which are currently the biggest health problems in the world. However, the health of patients with chronic diseases is not duty of physicians or health professional since each people will also is responsible by your health.

On the other hand, for help chronic diseases patients, we encourage the physicians and health professional look for these factors in your patients because a disease no appear alone and can be starting point for others. Diseases no remains in healthy body, thereby we suggested that the chronic patients substitute the soft drinks by water with pH alkaline, coconut water and pink salt Himalayan, as these nutrients are crucial for human body. Replace processed food rich in fat Trans by foods made by nature. For removed the pesticides used in plantation, placed foods in one liter of water with 5 mL tincture of iodine 2% by an hour preferably covered and without any contact with light (in the oven) due to the oxidation iodine. Replace vegetables shortening (Crisco) by coconut oil or butter pig for cooking, because excess of Omega-6 is harmful for your health and have been linked inflammation, cardiovascular diseases and diabetes. No have afraid eat fatty, but the good fatty like avocado, linseed, coconut oil and olive oil. Remove or decrease gluten intake can fight and treat gluten-related-disorders, wheat allergy, autism and helicobacter pylori infection.

A seasonal detoxification is crucial for clear your body of toxins speeding up your metabolism for enhance health. Taking one cup of water with one lemon in the morning rehydrates body promotes digestion and help in flow of waste of your body. Protocols of validated detoxification as garlic extract, glutathione, magnesium sulfate and saunas can help in various chronic diseases.

Plantation in monoculture and few fertilizers applied in land were crucial for decrease the vitamins, minerals of grains, fruits and vegetables. Foods are born poor and not replenish all that the body needs, however, the supplementation of micronutrients, vitamins and minerals offer potential to improve health of patients with deficiency nutritional. Sun exposure between 15-20 min/day at midday (heliotherapy) increase levels vitamin D preventing and treating various diseases, besides of be a way cheap for care of health.

Dental infections have been strongly linked with auto-immune diseases. In doubt, is crucial the physician refer the patient for dentist for check the teeth, fact that is have been common in Germany. Electromagnetic pollution can be reduced through Grahan/Stetzer (GS) filters installed in schools with sick building syndrome. Interestingly, the symptoms of asthma in the students were reduced, student behavior with ADHD improved and students with type 1 and 2 Diabetes control glycemic improved, on the other hand, Grahan/ Stetzer (GS) filters installed in house of patients with multiple sclerosis demonstrated better balance and fewer tremor.

Author Contributors

H.A.P performed literature search, analyzed data, wrote manuscript and had final responsibility for final content. M.C.F.F, L.R.L analyzed data, and assisted with writing the manuscript.


  1. Carrera-Bastos P, Fontes-Villalba M, O’Keefe JH (2011) Cordain The western diet and lifestyle and diseases of civilization. Res Reports ClinCardiol 2: 15-35.
  2. Sapone A, Bai JC, Ciacci C, Dolinsek J, Green PH, et al. (2012) Spectrum of gluten-related disorders: consensus on new nomenclature and classification. BMC Med 10: 13.
  3. HAPO Study Cooperative Research Group, Metzger BE, Lowe LP, Dyer AR, Trimble ER, et al. (2008) Hyperglycemia and adverse pregnancy outcomes.  N Engl J Med 358: 1991-2002.
  4. Cooper RL, Laws SC, Das PC, Narotsky MG, Goldman JM, et al. (2007) Atrazine and reproductive function: mode and mechanism of action studies. Birth Defects Res B DevReprodToxicol 80: 98-112.
  5. Gammon DW, Aldous CN, Carr WC Jr, Sanborn JR, Pfeifer KF (2005) A risk assessment of atrazine use in California: human health and ecological aspects. Pest ManagSci 61: 331-355.
  6. Sagarkar S, Gandhi D, Devi SS, Sakharkar A, Kapley A (2016) Atrazine exposure causes mitochondrial toxicity in liver and muscle cell lines. Indian J Pharmacol 48: 200-207.
  7. Tareke E, Rydberg P, Karlsson P, Eriksson S, Törnqvist M (2002) Analysis of acrylamide, a carcinogen formed in heated foodstuffs. J Agric Food Chem 50: 4998-5006.
  8. Mokarizadeh A, Faryabi MR, Rezvanfar MA, Abdollahi M (2015) A comprehensive review of pesticides and the immune dysregulation: mechanisms, evidence and consequences.  ToxicolMech Methods 25: 258-278.
  9. Rogers PJ, Blundell JE (1990) Umami and appetite: effects of monosodium glutamate on hunger and food intake in human subjects. PhysiolBehav 48: 801-804.
  10. Day PE, Matata B, Elahi M (2015) Re-Visiting Glutamate Toxicity: Implications of Monosodium Glutamate Consumption on Glutamate Metabolism and Metabolic Syndrome. J Endocrinol Diabetes Melllitus 3: 20-31.
  11. Blaylock RL (2009) A possible central mechanism in autism spectrum disorders, part 2: immunoexcitotoxicity. AlternTher Health Med 15: 60-67.
  12. Olney JW (1990) Excitotoxic amino acids and neuropsychiatric disorders. Annu Rev PharmacolToxicol 30: 47-71.
  13. Suez J, Korem T, Zeevi D, Zilberman-Schapira G, Thaiss CA, et al. (2014) Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature 514: 181-186.
  14. Trocho C, Pardo R, Rafecas I, Virgili J, Remesar X, et al. (1998) Formaldehyde derived from dietary aspartame binds to tissue components in vivo. Life Sci 63: 337-349.
  15. Humphries P, Pretorius E, Naudé H (2008) Direct and indirect cellular effects of aspartame on the brain.  Eur J ClinNutr 62: 451-462.
  16. Fagherazzi G, Vilier A, Saes Sartorelli D, Lajous M, Balkau B, et al. (2013) Consumption of artificially and sugar-sweetened beverages and incident type 2 diabetes in the Etude Epidemiologiqueaupres des femmes de la MutuelleGenerale de l'EducationNationale-European Prospective Investigation into Cancer and Nutrition cohort.  Am J ClinNutr 97: 517-523.
  17. Englund-Ogge L, LiseBrantsæter A, Haugen M, Sengpiel V, Khatibi A, et al. (2012) Association between intake of artificially sweetened and sugar- sweetened beverages and preterm delivery: a large prospective cohort study. Am J ClinNutr96: 552-559.
  18. Bray GA, Nielsen SJ, Popkin BM (2004) Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J ClinNutr 79: 537-543.
  19. Havel PJ (2005) Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism. Nutr Rev 63: 133-157.
  20. Vos MB, Kimmons JE, Gillespie C, Welsh J, Blanck HM (2008) Dietary fructose consumption among US children and adults: the Third National Health and Nutrition Examination Survey. Medscape J Med 10: 155-160.
  21. Ferder L, Ferder MD, Inserra F (2010) The role of high-fructose corn syrup in metabolic syndrome and hypertension.  CurrHypertens Rep 12: 105-112.
  22. Stanhope KL, Griffen SC, Bair BR, Swarbrick MM, Keim NL, et al. (2008) Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals.  Am J ClinNutr 87: 1194-1203.
  23. Angelopoulos TJ, Lowndes J, Zukley L, Melanson KJ, Nguyen V, et al. (2009) The effect of high-fructose corn syrup consumption on triglycerides and uric acid.  J Nutr 139: 1242S-1245S.
  24. Softic S, Cohen DE, Kahn CR (2016) Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease. Dig Dis Sci 61: 1282-1293.
  25. Malik VS, Hu FB (2015) Fructose and Cardiometabolic Health: What the Evidence From Sugar-Sweetened Beverages Tells Us. J Am CollCardiol 66: 1615-1624.
  26. Varma S, Hussain ME (2016) Obesity and diabetes: An update. Diabetes Metab. SyndrClin Res Rev:In Press.
  27. Malik VS, Popkin BM, Bray GA, Després JP, Willett WC, et al. (2010) Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes: a meta-analysis. Diabetes Care 33: 2477-2483.
  28. Choi HK, Willett W, Curhan G (2010) Fructose-rich beverages and risk of gout in women. JAMA 304: 2270-2278.
  29. Hu FB (2013) Resolved: there is sufficient scientific evidence that decreasing sugar-sweetened beverage consumption will reduce the prevalence of obesity and obesity-related diseases.  Obes Rev 14: 606-619.
  30. Malik VS, Schulze MB, Hu FB (2006) Intake of sugar-sweetened beverages and weight gain: a systematic review. Am J ClinNutr 84: 274-288.
  31. Chun S, Choi Y, Chang Y, Cho J, Zhang Y, et al. (2016) Sugar-sweetened carbonated beverage consumption and coronary artery calcification in asymptomatic men and women.  Am Heart J 177: 17-24.
  32. James J, Thomas P, Cavan D, Kerr D (2004) Preventing childhood obesity by reducing consumption of carbonated drinks: cluster randomised controlled trial. BMJ 328: 1237.
  33. Ahmed S, Atlas E (2016) Bisphenol S- and bisphenol A-induced adipogenesis of murine preadipocytes occurs through direct peroxisome proliferator-activated receptor gamma activation. Int J Obes.
  34. Bucher S, Jalili P, Le Guillou D, Begriche K, Rondel K, et al. (2016) Bisphenol a induces steatosis in HepaRG cells using a model of perinatal exposure. Environ Toxicol.
  35. Menale C, Grandone A, Nicolucci C, Cirillo G, Crispi S, et al. (2016) Bisphenol A is associated with insulin resistance and modulates adiponectin and resistin gene expression in obese children. PediatrObes.
  36. Fujiwara T, Morisaki N, Honda Y, Sampei M, Tani Y (2016) Chemicals, Nutrition, and Autism Spectrum Disorder: A Mini-Review. Front Neurosci 10: 174.
  37. Watkins DJ, Milewski S, Domino SE, Meeker JD, Padmanabhan V (2016) Maternal phthalate exposure during early pregnancy and at delivery in relation to gestational age and size at birth: A preliminary analysis. ReprodToxicol 65: 59-66.
  38. Kuo FC, Su SW, Wu CF, Huang MC, Shiea J, et al. (2015) Relationship of urinary phthalate metabolites with serum thyroid hormones in pregnant women and their newborns: a prospective birth cohort in Taiwan. PLoS One 10: e0123884.
  39. Singh R, Gautam N, Mishra A, Gupta R (2011) Heavy metals and living systems: An overview. Indian J Pharmacol 43: 246-253.
  40. Thomas A (2007) Fats and Fatty Oils. In Ullmann’sEncyclopedia of Industrial Chemistry. Wiley- VCH Verlag GmbH & Co. KGaA: Weinheim, Germany.
  42. Simopoulos A (2002) The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother 56: 365-379.
  43. Simopoulos AP (2006) Evolutionary aspects of diet, the omega-6/omega-3 ratio and genetic variation: nutritional implications for chronic diseases.  Biomed Pharmacother 60: 502-507.
  44. Calder PC (2006) n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J ClinNutr 83: 1505S-1519S.
  45. Lands WE (2005) Dietary fat and health: the evidence and the politics of prevention: careful use of dietary fats can improve life and prevent disease.  Ann N Y AcadSci 1055: 179-192.
  46. Mensink RP, Katan MB (1990) Effect of dietary trans fatty acids on high-density and low-density lipoprotein cholesterol levels in healthy subjects.  N Engl J Med 323: 439-445.
  47. Lopez-Garcia E, Schulze MB, Meigs JB, Manson JE, Rifai N, et al. (2005) Consumption of trans fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction. J Nutr 135: 562-566.
  48. Ascherio A, Willett WC (1997) Health effects of trans fatty acids. Am J ClinNutr 66: 1006S-1010S.
  49. Wijga AH, van Houwelingen AC, Kerkhof M, Tabak C, de Jongste JC, et al. (2006) Breast milk fatty acids and allergic disease in preschool children: the Prevention and Incidence of Asthma and Mite Allergy birth cohort study.  J Allergy ClinImmunol 117: 440-447.
  50. deLorgeril M, Salen P (2012) New insights into the health effects of dietary saturated and omega-6 and omega-3 polyunsaturated fatty acids. BMC Med 10: 50.
  51. Gago-Dominguez M, Yuan JM, Sun CL, Lee HP, Yu MC (2003) Opposing effects of dietary n-3 and n-6 fatty acids on mammary carcinogenesis: The Singapore Chinese Health Study. Br J Cancer 89: 1686-1692.
  52. Hibbeln JR, Nieminen LR, Lands WE (2004) Increasing homicide rates and linoleic acid consumption among five Western countries, 1961-2000. Lipids 39: 1207-1213.
  53. Kiecolt-Glaser JK, Belury MA, Porter K, Beversdorf DQ, Lemeshow S, et al. (2007) Depressive symptoms, omega-6:omega-3 fatty acids, and inflammation in older adults. Psychosom Med 69: 217-224.
  54. Catassi C, Bai JC, Bonaz B, Bouma G, Calabrò A, et al. (2013) Non-Celiac Gluten sensitivity: the new frontier of gluten related disorders.  Nutrients 5: 3839-3853.
  55. Barada K, Abu Daya H, Rostami K, Catassi C (2012) Celiac disease in the developing world.  GastrointestEndoscClin N Am 22: 773-796.
  56. Spaenij-Dekking L, Kooy-Winkelaar Y, van Veelen P, Drijfhout JW, Jonker H, et al. (2005) Natural variation in toxicity of wheat: potential for selection of nontoxic varieties for celiac disease patients.  Gastroenterology 129: 797-806.
  57. Leonard MM, Vasagar B (2014) US perspective on gluten-related diseases. ClinExpGastroenterol 7: 25-37.
  58. Zuidmeer L, Goldhahn K, Rona RJ, Gislason D, Madsen C, et al. (2008) The prevalence of plant food allergies: a systematic review.  J Allergy ClinImmunol 121: 1210-1218.
  59. Mendes FB, Hissa-Elian A, Abreu MA, Gonçalves VS (2013) Review: dermatitis herpetiformis.  An Bras Dermatol 88: 594-599.
  60. Hadjivassiliou M, Grünewald RA, Chattopadhyay AK, Davies-Jones GA, Gibson A, et al. (1998) Clinical, radiological, neurophysiological, and neuropathological characteristics of gluten ataxia.  Lancet 352: 1582-1585.
  61. Lau NM, Green PH, Taylor AK, Hellberg D, Ajamian M, et al. (2013) Markers of Celiac Disease and Gluten Sensitivity in Children with Autism. PLoS One 8: e66155.
  62. Rostami-Nejad M, JavadEhsani-Ardakani M, Assadzadeh H, Shahbazkhani B, Ierardi E, et al. (2016) Pathological and Clinical Correlation between Celiac Disease and Helicobacter Pylori Infection; a Review of Controversial Reports.Middle East J Dig Dis 8: 85-92.
  64. World Health Organization (2011)The global prevalence of anaemia in 2011.
  65. Pilz S, Verheyen N, Grübler MR (2016) Vitamin D and cardiovascular disease prevention.Nat Rev Cardiol 13: 404-417.
  66. Hendaus MA, Jomha FA, Ehlayel M (2016) Allergic diseases among children: nutritional prevention and intervention.TherClin Risk Manag 12: 361-372.
  67. Biricik E, Gunes Y (2015) Vitamin D and Anaesthesia.Turk J AnaesthesiolReanim 43: 269-273.
  68. Holick MF (2006) Resurrection of vitamin D deficiency and rickets.J Clin Invest 116: 2062-2072.
  69. Ascherio A, Munger KL, Simon KC (2010) Vitamin D and multiple sclerosis.Lancet Neurol 9: 599-612.
  70. Deleskog A, Hilding A, Brismar K, Hamsten A, Efendic S, et al. (2012) Low serum 25-hydroxyvitamin D level predicts progression to type 2 diabetes in individuals with prediabetes but not with normal glucose tolerance.Diabetologia 55: 1668-1678.
  71. Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF (2000) Decreased bioavailability of vitamin D in obesity.Am J ClinNutr 72: 690-693.
  72. Fattizzo B, Zaninoni A, Giannotta JA, Binda F, Cortelezzi A, et al. (2016) Reduced 25-OH vitamin D in patients with autoimmune cytopenias, clinical correlations and literature review.Autoimmun Rev 15: 770-775.
  73. Bjelakovic G, Gluud LL, Nikolova D, Whitfield K, Krstic G, et al. (2014) Vitamin D supplementation for prevention of cancer in adults. Cochrane database Syst Rev 6: 7469.
  74. deBaaij JH, Hoenderop JG, Bindels RJ (2015) Magnesium in man: implications for health and disease.Physiol Rev 95: 1-46.
  75. Mauskop A, Altura BT, Cracco RQ, Altura BM (1995) Intravenous Magnesium Sulfate Relieves Cluster Headaches in Patients With Low Serum Ionized Magnesium Levels. Headache J Head Face Pain 35: 597–600.
  76. Oladipo OO, Ajala MO, Okubadejo N, Danesi MA, Afonja OA (2003) Plasma magnesium in adult Nigerian patients with epilepsy.Niger Postgrad Med J 10: 234-237.
  77. Tarleton EK, Littenberg B (2015) Magnesium intake and depression in adults.J Am Board Fam Med 28: 249-256.
  78. Barbagallo M, Belvedere M, Di Bella G, Dominguez LJ (2011) Altered ionized magnesium levels in mild-to-moderate Alzheimer's disease.Magnes Res 24: S115-121.
  79. Shah NC, Shah GJ, Li Z, Jiang XC, Altura BT, et al. (2014) Short-term magnesium deficiency downregulates telomerase, upregulates neutral sphingomyelinase and induces oxidative DNA damage in cardiovascular tissues: relevance to atherogenesis, cardiovascular diseases and aging.Int J ClinExp Med 7: 497-514.
  80. Jee SH, Miller ER, Guallar E, Singh VK, Appel LJ, et al. (2002) The effect of magnesium supplementation on blood pressure: a meta-analysis of randomized clinical trials.Am J Hypertens 15: 691-696.
  81. Palmer BF, Clegg DJ (2015) Electrolyte and Acid-Base Disturbances in Patients with Diabetes Mellitus.N Engl J Med 373: 548-559.
  82. Ramadass S, Basu S, Srinivasan AR (2015) SERUM magnesium levels as an indicator of status of Diabetes Mellitus type 2.Diabetes Metab Syndr 9: 42-45.
  83. Nogovitsina OR, Levitina EV (2005) Diagnostic value of examination of the magnesium homeostasis in children with attention deficit syndrome with hyperactivity.Klin Lab Diagnpp: 17-19.
  84. Starobrat-Hermelin B, Kozielec T (1997) The effects of magnesium physiological supplementation on hyperactivity in children with attention deficit hyperactivity disorder (ADHD). Positive response to magnesium oral loading test.Magnes Res 10: 149-156.
  85. Cheuk DK, Chau TC, Lee SL (2005) A meta-analysis on intravenous magnesium sulphate for treating acute asthma.Arch Dis Child 90: 74-77.
  86. Altman D, Carroli G, Duley L, Farrell B, Moodley J, et al. (2002) Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial.Lancet 359: 1877-1890.
  87. Park YH, Kim N (2015) Review of atrophic gastritis and intestinal metaplasia as a premalignant lesion of gastric cancer.J Cancer Prev 20: 25-40.
  89. Teixeira BC, Norton RC, Penna FJ, Camargos PA, Lasmar LM, et al. (2007) Gastroesophageal reflux and asthma in childhood: a study on their relationship using esophageal PH monitoring.J Pediatr (Rio J) 83: 535-540.
  90. Katz PO, Gerson LB, Vela MF (2013) Guidelines for the diagnosis and management of gastroesophageal reflux disease.Am J Gastroenterol 108: 308-328.
  91. Betesh AL, Santa Ana CA, Cole JA, Fordtran JS (2015) Isachlorhydria a cause of iron deficiency anemia?Am J ClinNutr 102: 9-19.
  92. Lerner A, Matthias T (2015) Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease. Autoimmun Rev 14: 479– 489.
  93. Li X, Atkinson MA (2015) The role for gut permeability in the pathogenesis of type 1 diabetes--a solid or leaky concept?Pediatr Diabetes 16: 485-492.
  94. Kibblewhite MG, Ritz K, Swift MJ (2008) Soil health in agricultural systems.Philos Trans R SocLond B BiolSci 363: 685-701.
  95. Nyström HF, Brantsæter AL, Erlund I, Gunnarsdottir I, Hulthen L, et al. (2016) Iodine status in the Nordic countries - past and present.Food Nutr Res 60: 31969.
  96. Dillman E, Gale C, Green W, Johnson DG, Mackler B, et al. (1980) Hypothermia in iron deficiency due to altered triiodothyronine metabolism.Am J Physiol 239: R377-381.
  97. Zimmermann MB, Köhrle J (2002) The impact of iron and selenium deficiencies on iodine and thyroid metabolism: biochemistry and relevance to public health.Thyroid 12: 867-878.
  98. Walker SP, Wachs TD, Gardner JM, Lozoff B, Wasserman GA, et al. (2007) Child development: risk factors for adverse outcomes in developing countries.Lancet 369: 145-157.
  99. Zimmermann MB, Jooste PL, Mabapa NS, Mbhenyane X, Schoeman S, et al. (2007) Treatment of iodine deficiency in school-age children increases insulin-like growth factor (IGF)-I and IGF binding protein-3 concentrations and improves somatic growth.J ClinEndocrinol Metab 92: 437-442.
  100. Pironi L, Guidetti M, Agostini F (2015) Iodine status in intestinal failure in adults.CurrOpinClinNutr Metab Care 18: 582-587.
  101. Herter-Aeberli I, Cherkaoui M, E Ansari N, Rohner R, Stinca S, et al. (2015) Iodine Supplementation Decreases Hypercholesterolemia in Iodine-Deficient, Overweight Women: A Randomized Controlled Trial.J Nutr 145: 2067-2075.
  102. Zimmermann MB, Jooste PL, Pandav CS (2008) Iodine-deficiency disorders.Lancet 372: 1251-1262.
  103. Winning L, Linden GJ (2015) Periodontitis and systemic disease. BDJ Team 2: 151-163.
  104. Kim J, Amar S (2006) Periodontal disease and systemic conditions: a bidirectional relationship.Odontology 94: 10-21.
  105. Schulze A, Schönauer M, Busse M (2007) Sudden improvement of insulin sensitivity related to an endodontic treatment.J Periodontol 78: 2380-2384.
  106. Murray CA, Saunders WP (2000) Root canal treatment and general health: a review of the literature.IntEndod J 33: 1-18.
  107. Siqueira JF, Roças IN (2005) Uncultivated phylotypes and newly named species associated with primary and persistent endodontic infections.J ClinMicrobiol 43: 3314-3319.
  108. Willershausen I, Weyer V, Peter M, Weichert C, Kasaj A, et al. (2014) Association between chronic periodontal and apical inflammation and acute myocardial infarction.Odontology 102: 297-302.
  109. Pessi T, Karhunen V, Karjalainen PP, Ylitalo A, Airaksinen JK, et al. (2013) Bacterial signatures in thrombus aspirates of patients with myocardial infarction.Circulation 127: 1219-1228, e1-6.
  110. Tobaldini E, Costantino G, Solbiati M, Cogliati C, Kara T, et al. (2016) Sleep, sleep deprivation, autonomic nervous system and cardiovascular diseases.NeurosciBiobehav Rev.
  111. Wellen KE, Hotamisligil GS (2005) Inflammation, stress, and diabetes.J Clin Invest 115: 1111-1119.
  112. Leff-Gelman P, Mancilla-Herrera I, Flores-Ramos M, Cruz-Fuentes C, et al. (2016) The Immune System and the Role of Inflammation in Perinatal Depression.Neurosci Bull 32: 398-420.
  113. Masuda M, Wakasaki T, Toh S (2016) Stress-triggered atavistic reprogramming (STAR) addiction: driving force behind head and neck cancer?Am J Cancer Res 6: 1149-1166.
  114. Dube SR, Fairweather D, Pearson WS, Felitti VJ, Anda RF, et al. (2009) Cumulative childhood stress and autoimmune diseases in adults.Psychosom Med 71: 243-250.
  115. Stojanovich L, Marisavljevich D (2008) Stress as a trigger of autoimmune disease.Autoimmun Rev 7: 209-213.
  116. Chauhan A, Chauhan V (2006) Oxidative stress in autism.Pathophysiology 13: 171-181.
  117. Taylor L (2016) No place to hide? The ethics and analytics of tracking mobility using mobile phone data. Environ Plan D SocSp 34: 319-336.
  118. Redlarski G, Lewczuk B, Zak A, Koncicki A, Krawczuk M, et al. (2015) The influence of electromagnetic pollution on living organisms: historical trends and forecasting changes.Biomed Res Int.
  119. Havas M (2006) Electromagnetic hypersensitivity: biological effects of dirty electricity with emphasis on diabetes and multiple sclerosis.ElectromagnBiol Med 25: 259-268.
  120. Li L, Dai Y, Xia R, Chen S, Qiao D (2005) Pulsed electric field exposure of insulin induces anti-proliferative effects on human hepatocytes.Bioelectromagnetics 26: 639-647.
  121. Sakurai T, Satake A, Sumi S, Inoue K, Miyakoshi J (2004) An extremely low frequency magnetic field attenuates insulin secretion from the insulinoma cell line, RIN-m.Bioelectromagnetics 25: 160-166.
  122. Blank M, Goodman R (2004) Comment: a biological guide for electromagnetic safety: the stress response.Bioelectromagnetics 25: 642-646.
  123. Hinkle Le, Wolf S (1949) Studies in diabetes mellitus; changes in glucose, ketone, and water metabolism during stress.Res PublAssoc Res NervMent Dis 29: 338-389.
Citation: Peres HA, Pereira LRL, Foss MCF (2016) Toxins, Malnutrition, Stress, Infections and Electromagnetic Pollution: Looking about New Perspectives in Development of Diseases. J Nutr Food Sci 6:558.

Copyright: © 2016 Peres HA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.