Journal of Nutrition & Food Sciences
Open Access
ISSN: 2155-9600
ISSN: 2155-9600
Yung-Kai Lin, Chia-Hua Liang, Yung-Hsiang Lin, Shu-Ting Chan, and Chi-Fu Chiang
With aging, skin elasticity decreases, and fine lines emerge. Recently, sialic acid has gained attention for its role in boosting skin hydration, elasticity, and radiance. The “gut-skin axis” concept also underscores how probiotics can enhance skin beauty by modulating the gut microbiome, reducing inflammation, and supporting healthier skin. This study aimed to evaluate the effects of the probiotic Ligilactobacillus salivarius (TCI153) on skin health through both clinical and in vitro approaches. In human dermal fibroblasts, TCI153 significantly increased sialic acid production (~280 μg/mL), upregulated COL1A1 gene expression by 1.23-fold, enhanced elastin synthesis by 16%, and promoted collagen gel contraction by 5%, indicating potential benefits for skin firmness and extracellular matrix support. Clinically, sixty subjects were randomly divided into a TCI153 group and a placebo group, with each subject taking one sachet daily for eight consecutive weeks. Skin assessments, blood analyses, gut microbiota evaluations, and measurements of sialic acid and Epidermal Growth Factor (EGF) levels were conducted at baseline, week 4, and week 8. TCI153 significantly increased sialic acid and EGF levels, reduced melanin, improved skin lightness and elasticity, enhanced hydration, and decreased Transepidermal Water Loss (TEWL). Gut microbiota analysis also showed improved balance and a reduction in pathogenic bacteria. These results suggest that TCI153 supports skin health through both systemic and cellular pathways, highlighting its potential in beauty and wellness applications.
Published Date: 2025-05-28; Received Date: 2025-04-28