Genetic Polymorphisms of One-carbon Enzymes Interactively Modify Metabolic Folate Stress and Risks of Hepatocellular Carcinoma Development

Chang-Sheng Kuo¹, Chin-Pao Cheng^1,2, Hsing-Tao Kuo³, Chien-Hung Chen⁴, Chi-Yun Huang⁵, Chun-Chieh Chen⁵ and Rwei-Fen Syu Huang^1,5*

¹Nutrition and Food Science, Fu Jen University, HsinChuang, Taiwan, E-mail: 034825@mail.fju.edu.tw

²Dietetic Department, National Taiwan University Hospital, Taipei, Taiwan, E-mail: 034825@mail.fju.edu.tw

³Section of Gastroenterology and Hepatology and Department of Internal Medicine, Chi-Mei Medical Center, Taiwan, E-mail: 034825@mail.fju.edu.tw

⁴Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, E-mail: 034825@mail.fju.edu.tw

⁵Department of Nutritional Science, Fu Jen University, Taiwan, E-mail: 034825@mail.fju.edu.tw

^*Corresponding Author: Rwei-Fen Syu Huang, Department of Nutritional Science, Fu-Jen University, Hsinchuang, Taiwan, Tel: 886229052512