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Enzymatic Deglycosylation of Opuntia ficus indica improves its Estrogen Receptor-Subtype Selective Transcriptional and Anti-Inflammatory Activities
Journal of Nutrition & Food Sciences

Journal of Nutrition & Food Sciences
Open Access

ISSN: 2155-9600

Research Article - (2016) Volume 6, Issue 6

Enzymatic Deglycosylation of Opuntia ficus indica improves its Estrogen Receptor-Subtype Selective Transcriptional and Anti-Inflammatory Activities

Hyesoo Jeong1, Byoung Ha An1, Wenmei Zhou1, Xiyuan Liu1, Yun Seon Song2 and Minsun Chang1*
1Sookmyung Women's University, Seoul, Republic of Korea, E-mail: [email protected]
2Wenzhou Medical University, Wenzhou City, China, E-mail: [email protected]
*Corresponding Author: Minsun Chang, Department of Biological Sciences, College of Science, Sookmyung Women's University, Republic of Korea, Tel: +82-2-2077- 7626, Fax: +82-303-0801-1074

Abstract

Flavonoids are polyphenols widely present as aglycone or sugar-attached glycosides in agricultural products and possess various beneficial activities. Glycosylation affects the physicochemical properties of flavonoid aglycones, leading to changes in their biological activities. Opuntia ficus indica (OFI) fruits are reported to have anti-diabetic, anti-inflammatory, and phytoestrogenic activities. In this study, the role of glycosylation in OFI grown in Jeju, Korea has been investigated, focusing on narcissin, which is the major flavonoid glycoside. Efficient and mild hydrolysis of the glycosides in extracts of Jeju OFI fruits (OFIE) was investigated using hydrolysis enzymes. The enzyme-treated OFIE displayed estrogen receptor β−selective transcriptional activity and inhibition of the nuclear factor-κB signaling pathway in cell line models. Additionally, it inhibited the enzyme that catalyzes the conversion of prostaglandin H2 to inflammatory prostaglandin D2. Our data suggests that enzymatic deglycosylation of OFIE may increase healthpromoting benefits such as the estrogen replacement effect with anti-inflammatory activity.

Keywords: Opuntia ficus indica; Deglycosylation; Enzyme hydrolysis; Estrogen receptor; NF-κB; Prostaglandin D2 synthase; Inflammation

Retraction Note

The article entitled “Enzymatic Deglycosylation of Opuntia ficus indica improves its Estrogen Receptor-Subtype Selective Transcriptional and Anti-Inflammatory Activities” has been accepted for publication in the Journal of Nutrition & Food Sciences considering the statements provided in the article as personal opinion of the author which was found not having any conflict or biasness towards anything. As the article was a perspective one, information provided by the author was considered as an opinion to be expressed through publication.

Publisher took decision to make the article online solely based on the reviewers suggestion which considered the article not but a personal opinion of the author. However, it is found that the author have some personal concerns and issues, therefore, being retracted from the journal.

Citation: Jeong H, An BH, Zhou W, Liu X, Song YS, et al. (2016) Enzymatic Deglycosylation of Opuntia ficus indica improves its Estrogen Receptor-Subtype Selective Transcriptional and Anti-Inflammatory Activities. J Nutr Food Sci 6: 568.

Copyright: © 2016 Jeong H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.