Journal of Probiotics & Health
Open Access

Department of Dermatology, Case Western Reserve University, Center for Medical Mycology,University Hospitals Cleveland Medical Center, Cleveland, USA

Publications

• Research   
  The Probiotic BIOHM Improves Nutrient Absorption by Disrupting Gastrointestinal Biofilms
  Author(s): Ghannoum M*, Ghannoum A, Hager C, Retuerto M, Isham N and McCormick TS
  
  Aim: To demonstrate the ability of a probiotic supplement (BIOHM) to disrupt pathogenic gastrointestinal biofilms, thus enhancing nutrient absorption. Methods: A filter insert model using Caco-2 cells to mimic an intestinal monolayer was employed to determine the ability of BIOHM to disrupt a mixed species (Candida tropicalis, Escherichia coli and Serratia marcescens) biofilm known to occur in patients with Crohn’s disease. Penetration of vitamin C and casein as representative of vitamins and proteins, respectively, was then measured. Results: Application of BIOHM led to a significant increase in casein penetration through the Caco-2 cell epithelial monolayer in the absence of biofilms (p value<0.0001). Additionally, the combination of mixed species biofilms grown on a Caco-2 cell monolayer with BIOHM filt.. View More»
  DOI: 10.35248/2329-8901.19.7.213

  Abstract HTML PDF