Journal of Drug Metabolism & Toxicology

Journal of Drug Metabolism & Toxicology
Open Access

ISSN: 2157-7609


Ziyan Zhang

Ziyan Zhang


  • Review Article
    Hyperglycemia as a Risk Factor of Ischemic Stroke
    Author(s): Ziyan Zhang, Jingqi Yan and Honglian ShiZiyan Zhang, Jingqi Yan and Honglian Shi

    Diabetes is considered a major risk factor for stroke and is associated with worsened stroke outcomes. Here, we discuss and summarize the mechanisms that have been associated with the increased risk of stroke due to the hyperglycemia in diabetes mellitus. In diabetic stroke models, hyperglycemia exaggerates the following damaging processes: acidosis, accumulation of reactive oxygen species/reactive nitrogen, inflammation and mitochondrial dysfunction. Understanding the mechanism of diabetes acting as a stroke risk factor will definitely assist to reveal issues related to drug metabolism and toxicity in diabetic stroke. In addition, it is suggested that future studies may focus on the mechanisms mediating blood-brain barrier and astrocytes dysfunction under hyperglycemic stroke... View More»
    DOI: 10.4172/2157-7609.1000153

    Abstract PDF

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