Journal of Leukemia
Open Access
ISSN: 2329-6917
ISSN: 2329-6917
Yogesh Jethava
Tanzania
Case Report
Acute Lymphoblastic Leukemia evolving from atypical Chronic Myelogenous Leukemia: Case Report and Review of the Literature
Author(s): Angela Pennisi, Sarah Jewell, Jonathon Gralewski, Daisy Alapat, Bellamy William, Yogesh Jethava and Pooja MotwaniAngela Pennisi, Sarah Jewell, Jonathon Gralewski, Daisy Alapat, Bellamy William, Yogesh Jethava and Pooja Motwani
Atypical chronic myeloid leukemia (aCML) is a rare chronic myeloproliferative disorder characterized by leukocytosis, absence of Philadelphia chromosome or BCR-ABL rearrangement, and marked myeloid dysplasia. The diagnosis of aCML is difficult and challenging, more so if the initial presentation is with blast crisis. In the absence of characteristic mutational profile, blast crisis of aCML can lead to significant diagnostic dilemma. We describe a case of refractory acute lymphoblastic leukemia (ALL), needing critical evaluation of hemopathological and cytogenetic abnormalities. It was hypothesized that patient had undiagnosed aCML and presented with lymphoid blast crisis. To our knowledge, this is the first described case of aCML presenting with lymphoid blast crisis... View More»
DOI:
10.4172/2329-6917.S1-007