Fisheries and Aquaculture Journal
Open Access
ISSN: 2150-3508
ISSN: 2150-3508
Yajuan Li
No.96 Jinzhai Road, Hefei, Anhui Province, 230026
IR Iran
Research Article
Myeloperoxidase Inactivation Affects Neutrophil Recruitment in Zebrafish Injury-Induced Model
Author(s): Yajuan Li, Ren DL, Chen M, Ge SC and Bing Hu
Yajuan Li, Ren DL, Chen M, Ge SC and Bing Hu
Uncontrolled migration and excess recruitment of neutrophils can lead to persistent inflammation, tissue damage and disease. Myeloperoxidase is a remarkable target for further understanding the immune cell migration. This study tests the hypothesis that myeloperoxidase may regulate the immune cell activity and provides a new perspective on the treatment of immune diseases by exploring the mechanism of neutrophil migration. Studies of leukocyte migration in vivo in the zebrafish model, which set a collection of advantages both mammalian and cell lines, have gained widespread attention. In this study, we used tg (coro1a: eGFP; lyz: dsred2) and tg (lyz: eGFP) lines labelling both macrophages and neutrophils to study the effect of mpx on neutrophil chemotaxis to wounds. We found that myeloperoxidase was required for neutrophil migration to the wound site in injury-induced inflamm.. View More»
DOI:
10.4172/2150-3508.1000190