Reproductive System & Sexual Disorders: Current Research
Open Access
ISSN: 2161-038X
+44 1300 500008
ISSN: 2161-038X
+44 1300 500008
Wagdi F Elkashef
Egypt
Research Article
Effect of Green Tea Extract on the Interferon-Induced Testicular
Apoptosis in the Adult Albino Rat: Immunohistochemical and Electron
Microscopic Study
Author(s): Hassan M Rezk, Mohamed Elsherbiny, Wagdi F Elkashef and Medhat TahaHassan M Rezk, Mohamed Elsherbiny, Wagdi F Elkashef and Medhat Taha
Background: Interferons (IFNs) are widely used in the treatment of various diseases and can disrupt spermatogenesis and inhibition Leydig cell steroidogenesis through the formation of reactive oxygen species (ROSs) that cause oxidative stress. Aim of the work: In this study we examine the effect of (IFN) on rat spermatogonia and investigate the possible protective effect of Grean tea on (IFN)-induced spermatogonia appotosis. Material and Methods: Forty-eight adult male albino rats (240-280 g) were used in this study. They were divided into three groups. Group I in which rats were served as a control and were given sterile normal saline. The rats in Group II were given 7.500 units of interferon (INF) α-2β, considered in clinical treatment dose range, 3 times weekly under inhalation anesthesia for 2 month (Group II a) an.. View More»
DOI:
10.4172/2161-038X.1000146