Journal of Leukemia
Open Access
ISSN: 2329-6917
+44 1300 500008
ISSN: 2329-6917
+44 1300 500008
Viggo Jonsson
Rikshospital, Institute of Clinical Medicine,
Postbox 4950 Nydalen NO 0424 Oslo
Norway
Review Article
Chronic Lymphocytic Leukemia, Advantages of Monoclones?
Author(s): Viggo Jonsson, Haneef Awan, Tom Borge Johannesen and Geir E TjonnfjordViggo Jonsson, Haneef Awan, Tom Borge Johannesen and Geir E Tjonnfjord
From a basic biological point of view, genetic traits from the human genome have been selected during a long evolution in the fight for fitness. Since the susceptibility for CLL has a genotype, a theoretical question about its advantage is relevant. This is a question about mutated monoclones and whether they are an advantage to man. We suggest that the genetic capability to provide such monoclones could be explained as reminiscence from the fetal life like a ?Bad for the postnates, good for the prenates? principle. Some examples are described, e.g. the fetomaternal processing of endogenous retrovirus in the production of placenta-specific transcripts of several genes in a ceasefire balance with potential infectious exogenous retrovirus. The regulation of some cytokine reactions affected lymphocytes and monocytes around the trophoblasts, which clearly has a specific clonal pattern. Feto-.. View More»
DOI:
10.4172/2329-6917.1000142