Journal of Cell Science & Therapy
Open Access
ISSN: 2157-7013
ISSN: 2157-7013
Urszula Czech
Poland
Research Article
Lipid and Gene Interactions during Differentiation of Human Subcutaneous Adipose Tissue Stromal Vascular Cells
Author(s): Anna Polus, Beata Kiec-Wilk, Urszula Czech, Anna Knapp, Urszula Cialowicz, Alexander Sigrüner, Tatiana Konovalova, Gerd Schmitz, Maciej Malecki and Aldona Dembinska-KiecAnna Polus, Beata Kiec-Wilk, Urszula Czech, Anna Knapp, Urszula Cialowicz, Alexander Sigrüner, Tatiana Konovalova, Gerd Schmitz, Maciej Malecki and Aldona Dembinska-Kiec
Examination of the changes in cellular lipid composition, allows for an understanding in their contribution to adipocyte differentiation in health and disease. In the future the analysis of body lipid composition could offer an additional tool to diagnosing disease with the predictive capacity for prognosis.
Exposition of cells to excess of energy substrates causes activation of evolutionarily conserved adaptive mechanisms in endoplasmic reticulum stress. In preadipocytes, metabolic stress, through the activation of endoplasmic reticulum stress connected with modification of lipid composition and lipid droplet formation leads to differentiation.
The aim of the study was to examine changes in cellular lipid composition in parallel with gene expression and enzyme activity during preadipocyte differentiation using “omics” results.
Differentiation condi.. View More»
DOI:
10.4172/2157-7013.1000132