Current Synthetic and Systems Biology
Open Access
ISSN: 2332-0737
ISSN: 2332-0737
Tarek M. El-Achkar
Tarek M. El-Achkar
Division of Nephrology
Indiana University School of Medicine
United states of America
Dr. Tarek M. El-Achkar is currently working at Division of Nephrology, Indiana University School of Medicine, Indianapolis. His research interest includes Our lab has been focusing on the role of Tamm-Horsfall protein (Uromodulin) in Kidney Injury and inflammation. We uncovered a novel protective role for Uromodulin in acute kidney injury by down-regulating the inflammatory response and modulating neutrophil infiltration. Our current investigations are aimed at defining the molecular mechanism involved in this regulation, with a long term goal of using such insights to design novel therapeutic tools to treat patient with Acute Kidney Injury. We are also interested in understanding and defining tubular cross-talk that occurs between various nephron segments, and the ensuing interaction with the renal immune system in physiological states and during kidney injury. We use several animal models for kidney injury, and various genetic, molecular and cell biology techniques, with special expertise in various forms of microscopy and quantitative image analysis. We also developed advanced expertise in performing immuno-fluorescence guided Laser Micro-dissection (LMD) to dissect specific nephron segments for down-stream genomic and proteomic analysis.. He is serving as an honorary reviewer for Current Synthetic and Systems Biology. He /she has authored of several research articles/books related to Our lab has been focusing on the role of Tamm-Horsfall protein (Uromodulin) in Kidney Injury and inflammation. We uncovered a novel protective role for Uromodulin in acute kidney injury by down-regulating the inflammatory response and modulating neutrophil infiltration. Our current investigations are aimed at defining the molecular mechanism involved in this regulation, with a long term goal of using such insights to design novel therapeutic tools to treat patient with Acute Kidney Injury. We are also interested in understanding and defining tubular cross-talk that occurs between various nephron segments, and the ensuing interaction with the renal immune system in physiological states and during kidney injury. We use several animal models for kidney injury, and various genetic, molecular and cell biology techniques, with special expertise in various forms of microscopy and quantitative image analysis. We also developed advanced expertise in performing immuno-fluorescence guided Laser Micro-dissection (LMD) to dissect specific nephron segments for down-stream genomic and proteomic analysis.
Our lab has been focusing on the role of Tamm-Horsfall protein (Uromodulin) in Kidney Injury and inflammation. We uncovered a novel protective role for Uromodulin in acute kidney injury by down-regulating the inflammatory response and modulating neutrophil infiltration. Our current investigations are aimed at defining the molecular mechanism involved in this regulation, with a long term goal of using such insights to design novel therapeutic tools to treat patient with Acute Kidney Injury. We are also interested in understanding and defining tubular cross-talk that occurs between various nephron segments, and the ensuing interaction with the renal immune system in physiological states and during kidney injury. We use several animal models for kidney injury, and various genetic, molecular and cell biology techniques, with special expertise in various forms of microscopy and quantitative image analysis. We also developed advanced expertise in performing immuno-fluorescence guided Laser Micro-dissection (LMD) to dissect specific nephron segments for down-stream genomic and proteomic analysis.