Journal of Drug Metabolism & Toxicology
Open Access

Srinivasan Dinesh Kumar

Biography

Assoc Professor Srinivasan Dinesh Kumar is the Deputy Education Director at the Department of Anatomy and Integration Lead Educator at the Yong Loo Lin School of Medicine, National University of Singapore.His research interests include e-learning platform, augmented reality for medical education, diabetes induced congenital heart defects, ageing, and tissue engineering. He has acquired several research grants and published over 50 peer-reviewed papers in international journals including Nature, ADDR, Biomaterials, JBC, Diabetologia, FRBM, etc. He has published 5 book chapters and presented his work at international, regional and local scientific meetings. He has an H-index of 25 with over 2,000 citations.

Research Interest

Our laboratory focuses on the fundamental events involved in cell fate determination, differentiation and organogenesis. We investigate the molecular mechanisms of neural crest and cardiac development. Specifically, we focus on molecular mechanism by which maternal diabetes affect the health of unborn fetuses, particularly those involving microRNAs. We also investigate the importance of epigenetic mechanisms in maintaining gene expression profiles in cardiomyocytes. We are currently using mouse model to study the importance of these epigenetic marks in regulating the cardiac phenotype in disease states. We also investigate the causes of cardiovascular disease by applying modern genetic technologies. The current work of the laboratory focuses on three major questions: Are microRNAs involved in congenital defects? How do microRNAs recognize their targets? How could anomalies be prevented even in the setting of maternal diabetes? Students engaged in research in this laboratory can be expected to gain understanding of mouse and human genetics, with a specific focus on how these areas of research can be translated to the clinical setting. The current work of the laboratory focuses on three major questions: Are microRNAs involved in congenital defects? How do microRNAs recognize their targets? How could anomalies be prevented even in the setting of maternal diabetes? Students engaged in research in this laboratory can be expected to gain understanding of mouse and human genetics, with a specific focus on how these areas of research can be translated to the clinical setting.

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