Journal of Clinical and Experimental Ophthalmology

Journal of Clinical and Experimental Ophthalmology
Open Access

ISSN: 2155-9570

+44 1223 790975

Sonja Heinzelmann

  • Case Report
    Simultaneous Treatment of Severe Vemurafenib-induced Uveitis and Metastatic Melanoma
    Author(s): Moritz C Daniel, Sonja Heinzelmann and Thomas NeßMoritz C Daniel, Sonja Heinzelmann and Thomas Neß

    Background: Vemurafenib, a serine-threonine kinase inhibitor, has been used to treat unresectable metastatic melanoma since 2011. Ocular adverse events are reported to be seldom and to regress after the discontinuation of vemurafenib and therapy with topical steroids. However, this approach must be weighed against the potential progression of melanoma. We present alternative options in uveitis treatment enabling the continuation of vemurafenib therapy. Case report: We describe the clinical course of vemurafenib-induced uveitis in two patients initially presenting with macular oedema and scleritis. Both patients were treated successfully without discontinuing vemurafenib. Intraocular inflammation and macular oedema receded slowly after intraocular injection of 700 mg dexamethasone into the first patient's right eye. A moderate rise in intrao.. View More»
    DOI: 10.4172/2155-9570.1000513

    Abstract PDF

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