Virology & Mycology
Open Access

Sobia Idrees

Publications

• Review Article
  HCV Infection and NS-3 Serine Protease Inhibitors
  Author(s): Sobia Idrees and Usman A AshfaqSobia Idrees and Usman A Ashfaq
  
  Infection with Hepatitis C Virus (HCV) is a major health problem affecting 270 million people worldwide and 10 million people in Pakistan. Currently, there is no vaccine available for prevention of HCV infection due to the high degree of strain variation. The current standard of care is a combination of Pegylated interferon ? (PEG-INF ?) with ribavirin and Boceprevir/Telaprevir. Hence, there is a need to develop new antiviral agents from different targets. HCV NS3, a nonstructural protein has serine/protease and helicase domain, and these domains are considered as important antiviral drug targets to combat HCV. In the past 15 years, major scientific advances have enabled the development of many novel serine/protease and helicase inhibitors by using in vivo as well as in vitro model systems. Most of NS3 protease inhibitors have entered in different clinical trials phases but still ther.. View More»
  DOI: 10.4172/2161-0517.1000112

  Abstract PDF

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