Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Simone Wärntges
University of Erlangen-Nuremberg, Department of Ophthalmology, Interdisciplinary Center of Ophthalmologic, Preventive Medicine and Imaging (IZPI),
Schwabachanlage 6, D-91054 Erlangen
Germany
Case Report
Cluster Analysis of Glaucoma Patients Using the Retinal Nerve Fiber Layer Thickness of the Optic Nerve and DTI Parameters of the Optic Radiation
Author(s): Georg Michelson, Simone Wärntges, Tobias Engelhorn, Ahmed El Rafei, Joachim Hornegger and Arnd DoerflerGeorg Michelson, Simone Wärntges, Tobias Engelhorn, Ahmed El Rafei, Joachim Hornegger and Arnd Doerfler
Background: In glaucoma the optic radiation may be affected by ascending degeneration and/or ageing. This study classified groups of patients who are distinguishable related to their age, retinal nerve fiber layer thickness (RNFL), axonal integrity (measured by fractional anisotropy and mean diffusivity) and demyelination (measured by radial diffusivity) of the optic radiations. The goal was to separate glaucoma-induced damage of the optic radiations from impairment caused by the ageing effect.Design: Prospective comparative observational study. Participants: Fourty-five patients diagnosed with glaucoma of different entities and 17 patients with vital papilla (mean age 57.5 ± 13.8 years).Methods: Multimodal MRI including diffusion tensor imaging (DTI) of the optic radiations and measurement of the RNFL thickness by Sp.. View More»
DOI:
10.4172/2155-9570.S4-001