Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
+44 1223 790975
ISSN: 2155-9570
+44 1223 790975
Shigeru Honda
Division of Ophthalmology, Kobe University Graduate School of Medicine,
7-5-2 Kusunokicho, Chuo-ku, Kobe 650-0017
Japan
Research Article
Positive Association of Complement Factor H Gene Variants with the Effect of Photodynamic Therapy in Polypoidal Choroidal Vasculopathy
Author(s): Hiroaki Bessho, Shigeru Honda, Naoshi Kondo, Kunihiro Nishimura and Akira NegiHiroaki Bessho, Shigeru Honda, Naoshi Kondo, Kunihiro Nishimura and Akira Negi
Purpose: To clarify the association of complement factor H (CFH) gene polymorphisms with the effects of photodynamic therapy (PDT) in polypoidal choroidal vasculopathy (PCV). Methods: Ninety-three PCV subjects treated with PDT were recruited. Patients who showed anatomical success after the treatments with a single or two consecutive PDT sessions were classified as PDT responders. All others were classified as non-PDT responders. Three single nucleotide polymorphisms (SNPs), rs800292 (I62V), rs1061170 (Y402H) and rs1410996 were genotyped using the TaqMan assay. Results: The genotype and allelic frequency of rs1061170 (Y402H) and rs1410996 were significantly different between PDT responders and non-responders. In these SNPs, the risk alleles for PCV prevalence were beneficial for PDT response. In t.. View More»
DOI:
10.4172/2155-9570.1000122