Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
+44 1223 790975
ISSN: 2155-9570
+44 1223 790975
Shai M Bar-Sela
Tel-Aviv Sourasky Medical Center,
Weizman Street, Tel-Aviv
Israel
Research Article
Retinal Toxicity of Intravitreal Melphalan in Albino Rabbits
Author(s): Shai M Bar-Sela, Shiri Zayit-Soudry, Amir Massarweh, Irit Mane, Ido Perlman and Anat LoewensteinShai M Bar-Sela, Shiri Zayit-Soudry, Amir Massarweh, Irit Mane, Ido Perlman and Anat Loewenstein
Background: Intravitreal melphalan injections have been used for treating retinoblastoma with vitreous seeds. The aim of this study was to evaluate the safety margins for intravitreal melphalan, using clinical observations, electrophysiological testing and morphological observations.
Methods: In this experimental study, 18 albino rabbits, were treated with intravitreal injection of 0.1 ml melphalan solution to the right, experimental eye, and were divided into 4 dose groups: 5 μg (N=4); 15 μg (N=4); 30 μg (N=5); 60 μg (N=5). The left, control eye, of each rabbit was injected with 0.1 ml saline. Clinical examination, electroretinography (ERG) and visual evoked potentials (VEP) were conducted at baseline and periodically throughout the 4-week follow-up. The eyes were then enucleated and the retinas were prepared for histology and glia.. View More»
DOI:
10.4172/2155-9570.1000707