Journal of Clinical and Experimental Ophthalmology
Open Access

Sara Moghaddam-Taaheri

Publications

• Research Article
  Effects of Docosahexaenoic Acid in Preventing Experimental Choroidal Neovascularization in Rodents
  Author(s): Sara Moghaddam-Taaheri, Monica Agarwal, Juan Amaral, Irina Fedorova, Elvira Agrón, Norman Salem Jr., Emily Chew and S. Patricia BecerraSara Moghaddam-Taaheri, Monica Agarwal, Juan Amaral, Irina Fedorova, Elvira Agrón, Norman Salem Jr., Emily Chew and S. Patricia Becerra
  
  Background: The purpose of this study is to evaluate the effects of docosahexaenoic acid (DHA), a major omega-3- polyunsaturated fatty acid (ω-3-PUFAs), in the development of experimental choroidal neovascularization (CNV) in rodents. Methods: Experimental second generation Long Evans rats fed with diets of varying ω-3-PUFA content designed to produce significantly different retinal DHA levels were used in our studies. A transgenic mouse model (fat-1) engineered to over-produce DHA was also studied. CNV was induced by rupture of Bruch\'s membrane using laser photocoagulation. At 7 days after induction, animals were euthanatized, and eyes were collected. RPE/choroid flatmounts were labeled with isolectin IB4 to determine CNV lesion volumes using confocal microscopy and high-performance 3D imaging software. Results:.. View More»
  

  Abstract PDF

Relevant Topics