Journal of Leukemia
Open Access
ISSN: 2329-6917
ISSN: 2329-6917
Sara M. Bendary
Egypt
Research Article
Role of Interleukin17F (IL17F) Gene Polymorphism in Susceptibility to Acute Myeloid Leukemia
Author(s): Karima A. Mahfouz, Abdelraoof A. Abo-Nar and Sara M. BendaryKarima A. Mahfouz, Abdelraoof A. Abo-Nar and Sara M. Bendary
Abstract: Th17 cells (subset of CD4+ cells) are characterized by interleukin (IL)-17A and IL-17F production, which share strong homology, and surface expression of the IL-23 receptor (IL-23R). They have been implicated in the pathogenesis of inflammatory, autoimmune diseases and in many different types of human tumors, including lymphoma and myeloma.
Objectives: The aim of this study was to determine the association between the polymorphic features located within the IL-17A, IL-17F and IL-23R genes and susceptibility to or association with AML and the relationship between these polymorphic variants and the plasma IL-17 levels in all studied groups.
Subjects and Methods: 82 individual of Egyptian population including 27 AML patients, 40 individual who are relatives of those patients and 15 apparently healthy controls. All.. Read More»
DOI:
10.35248/2329-6917.19.7.252
