Journal of Leukemia

Journal of Leukemia
Open Access

ISSN: 2329-6917

+44 1300 500008

Ronald Kerr

Ronald Kerr

United Kingdom

  • Case Report
    A Rare Presentation of Cutaneous Pseudolymphoma as a Preleukaemic State
    Author(s): Muthu Sivaramakrishnan, Ronald Kerr, Alan Evans and Andrew AffleckMuthu Sivaramakrishnan, Ronald Kerr, Alan Evans and Andrew Affleck

    A patient presented with progressive and unresponsive erythematous rash affecting his trunk and limbs over a period of 5 years. His systemic examination and extensive relevant investigations were normal throughout this period. Skin biopsies at different times showed features of annular erythema, cutaneous pseudolymphoma and sub-acute dermatitis. Five years after the initial presentation, he developed erythroderma, leonine facies, lymphadenopathy and peripheral lymphocytosis. CT chest and abdomen revealed generalised lymphadenopathy. Skin biopsy and immunophenotyping was suggestive of Sezary syndrome. However, peripheral blood smear examination was highly suggestive of T-cell prolymphocytic leukaemia (TPLL). Subsequent molecular genetic analysis was consistent with TPLL. To the best of our knowledge, there are no reports of cutaneous pseudolymphoma transforming to TPLL in the literature. .. View More»
    DOI: 10.4172/2329-6917.1000122

    Abstract PDF

Relevant Topics