Journal of Thermodynamics & Catalysis
Open Access
ISSN: 2157-7544
ISSN: 2157-7544
Qi Li
China
Research Article
Studies on Efficacy Mechanism of Chinese Herbal Combination Based on Drug metabolizing Enzyme
Author(s): Xiaogang Weng, Yue Gao, Yujie Li, Xiaoni Liu, Ying Chen, Qing Yang, Yu Dong, Zipeng Gong, Yajie Wang, Qi Li, Feng Sui and Xiaoxin ZhuXiaogang Weng, Yue Gao, Yujie Li, Xiaoni Liu, Ying Chen, Qing Yang, Yu Dong, Zipeng Gong, Yajie Wang, Qi Li, Feng Sui and Xiaoxin Zhu
Mixed Formula is the main form and method of Traditional Chinese Medicine (TCM) treatment. It can produce different therapeutic effects by changing the combination of TCM Formula. Wuji Wan is a formula of TCM and was composed of Rhizoma Coptidis (Huanglian in Chinese, HL), Fructus Evodiae Rutaecarpae (Wuzhuyu, WZY) and Radix Paeoniae Alba (Baishao, BS). Wuji Wan is mainly used for the treatment of intestinal diseases. This paper took Wuji Wan as example study on efficacy Mechanism of TCM Combination Based on drug metabolizing Enzyme. Inhibition of cytochrome P450 (CYP) is regarded as the most clinically important pharmacokinetic causes among the various possible factors for drug-drug or herb-herb/herb-drug interactions. In this study, the in vitro inhibitory effects of Wuji Wan with different combination within HL, WZY and BS on six major rat CYPs (.. View More»
DOI:
10.4172/2157-7544.1000160