Autism-Open Access
Open Access

Paul H. Patterson

Publications

• Research Article
  Immune Involvement in Autism Spectrum Disorder as a Basis for Animal Models
  Author(s): Elaine Y. Hsiao* and Paul H. Patterson Elaine Y. Hsiao* and Paul H. Patterson
  
  Several of the environmental stimuli suggested to play a role in the pathogenesis of ASD involve altered immune responses during gestation. In this review, we discuss maternal immune activation as a primary risk factor for ASD, with an emphasis on recent findings from animal models of prenatal immune challenges. We further address the presence of autoantibodies as an additional immune-related autism risk factor, drawing upon work done in rodent and monkey models. We then explore the intersection between genetic and environmental susceptibility, with a focus on gene-environment interactions and immune involvement, in genetic risk factors for autism. Finally, we provide emerging evidence for the role of immune dysregulation in the pathogenesis of ASD. .. View More»
  DOI: 10.4172/2165-7890.S1-003

  Abstract PDF

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