Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Ozlem Tok
Turkey
Research Article
Comparison of Clinical, Microbiological, and Histopathological Effects of Topical Caspofungin, Anidulafungin, and Voriconazole in Candida albicans Keratitis
Author(s): Nazire Demirci, Ozlem Tok, Emel Sesli Cetin, Kemal Kursat Bozkurt, Sirin Baspinar, Levent Tok and Esra CiftciNazire Demirci, Ozlem Tok, Emel Sesli Cetin, Kemal Kursat Bozkurt, Sirin Baspinar, Levent Tok and Esra Ciftci
Purpose: The aim of this study was to compare the clinical, microbiological, and histopathological effects of topical caspofungin, anidulafungin, and voriconazole in the treatment of Candida albicans keratitis. Methods: Candida albicans (ATCC 10231) was inoculated on the mechanically de-epithelialized corneas of 28 male New Zealand White rabbits. Topical treatment was initiated after 72 h of inoculation. The rabbits were randomly assigned to treatment with 0.9% NaCl (control group), 0.5% caspofungin, 0.5% anidulafungin, or 1% voriconazole (n=6 rabbits per group). Eye drops were instilled every 30 minutes for the first 12 h, then hourly for 3 days. Clinical evaluations were done after 36 and 72 h of treatment. Clinical evaluation scores were calculated. Twelve hours after the final topical application, corneal tissue was removed.. View More»
DOI:
10.4172/2155-9570.1000655