Journal of Drug Metabolism & Toxicology
Open Access
ISSN: 2157-7609
+44-20-4587-4809
ISSN: 2157-7609
+44-20-4587-4809
Olga V Akopova
Bogomoletz Institute of Physiology,
NAS of Ukraine, Bogomoletz Street 4, 01601, Kiev
Ukraine
Review Article
Direct and Off-Target Effects of ATP-Sensitive Potassium Channels Opener Diazoxide
Author(s): Olga V AkopovaOlga V Akopova
Diazoxide (DZ) is a well-known cardioprotective drug capable of mimicking ischemic preconditioning. Being primarily a pharmacological opener of mitochondrial ATP-sensitive potassium channels (mKATP channels), DZ is known to produce multiple side effects because of its interactions with different cellular targets (such as plasma membrane KATP channels, F0F1 ATP synthase, succinate dehydrogenase and others), capable of confounding an understanding of direct bioenergetic effects of mKATP channels opening in mitochondria. In this review direct and offtarget effects of DZ were discussed. The emphasis was made on molecular basis of DZ interaction with KATP channels and different KATP channels isoforms sensitivity to this drug. The present knowledge on DZ interaction with mKATP channels is outlined as well as DZ interactions with other molecular targets affecting mitochondrial functions and .. View More»
DOI:
10.4172/2157-7609.1000227