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Journal of Drug Metabolism & Toxicology

Journal of Drug Metabolism & Toxicology
Open Access

ISSN: 2157-7609

+44-20-4587-4809

Norio Ogata

Norio Ogata
Research Institute, Taiko Pharmaceutical Co., Ltd.,
3-34-14 Uchihonmachi, Suita, Osaka 564-0032
Japan

Publications
  • Research Article
    Ten-week Whole-body Inhalation Toxicity Study of Chlorine Dioxide Gas in Rats
    Author(s): Norio Ogata, Tomoko Koizumi and Fumihiro OzawaNorio Ogata, Tomoko Koizumi and Fumihiro Ozawa

    Chlorine dioxide (ClO2) gas can protect against influenza virus infection at a concentration of 0.03 parts par million (volume/volume), which is believed to be nontoxic in humans. This suggests an opportunity for the development of a novel protective method against airborne infectious diseases. This method is especially applicable to the highly pathogenic H5N1 influenza virus, as there is currently no safe and effective protection against H5N1. However, concerns remain regarding the safety of ClO2 gas for protection against virus infection, especially whether a concentration of 0.03 parts per million is really non-toxic when it is used for humans in closed or semiclosed spaces. In view of the importance of the usefulness and necessity of low concentration ClO2 gas treatment, it is critical to determine the ?no observed adverse effect level? (NOAEL) of ClO2 gas. In 1972 Paulet and Desbrou.. View More»
    DOI: 10.4172/2157-7609.1000143

    Abstract PDF

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