Journal of Drug Metabolism & Toxicology
Open Access
ISSN: 2157-7609
+44-20-4587-4809
ISSN: 2157-7609
+44-20-4587-4809
Ngugi M Piero
School of Pure and Applied Sciences,
P.O. Box 43844-00100, Nairobi
Kenya
Research Article
In Vivo Antidiabetic Activity and Safety In Rats of Cissampelos pareira Traditionally Used In The Management of Diabetes Mellitus In Embu County, Kenya
Author(s): Ngugi M Piero, Njagi NM Eliud, Kimuni N Susan, Orinda O George, Njagi J Murugi, Maina David, Agyirifo D Sakyi, Gathumbi K Peter, Kinge W Stanley and Ngeranwa JN JosephNgugi M Piero, Njagi NM Eliud, Kimuni N Susan, Orinda O George, Njagi J Murugi, Maina David, Agyirifo D Sakyi, Gathumbi K Peter, Kinge W Stanley and Ngeranwa JN Joseph
Cissampelos pareira Linn has been used traditionally in the management of several diseases including diabetes mellitus but its efficacy and safety after long term use is not scientifically evaluated. The aim of this study was to determine in vivo hypoglycemic activity and safety of aqueous leaf extracts of C. pareira in white male albino rats. The extracts were screened for their hypoglycemic activity in alloxan induced diabetic rats using the oral and intraperitoneal routes. The safety of these extracts was studied in rats orally or intraperitoneally administered with 1 g/kg body weight daily for 28 days by recording the changes in body and organ weight, hematological and biochemical parameters and histology. Mineral composition of the extracts were estimated using total reflection X-ray fluorescence system (TRXF) while the types and quantities of phytochemicals present were assessed.. View More»
DOI:
10.4172/2157-7609.1000184