Journal of Leukemia
Open Access

Naser Kalhori

Publications

• Research Article
  Abnormal Free Light Chain Ratios are Significantly Associated with Clinical Progression in Chronic Lymphocytic Leukemia
  Author(s): Johannes Matschke, Lewin Eisele, Ludger Sellmann, Naser Kalhori, Arnd Nusch, Ulrich Dührsen, Jan Dürig and Holger Nückel Johannes Matschke, Lewin Eisele, Ludger Sellmann, Naser Kalhori, Arnd Nusch, Ulrich Dührsen, Jan Dürig and Holger Nückel
  
  Serum Free Light Chains (FLC) have prognostic significance in diverse plasma cell dyscrasias. Although monoclonal protein secretion is a typical feature of these diseases, it can also be detected in other B cell malignancies including chronic lymphocytic leukemia. Recent data suggests a significant correlation between abnormal ratio of FLC and outcome. Therefore, we investigated the role of FLC in a large cohort of 135 patients and the correlation to immunofixation (IF) and flow cytometry. Abnormal FLC ratios were found in 78 patients (58%) whereas the IF was positive in only 32 cases (24%). In 55 cases the FLC ratio was positive while IF was negative and in only 9 cases IF was positive while the FLC ratio was normal. In 52 of 98 patients (53%) light chain restriction determined by flow cytometry was concordant with the monoclonal FLC whereas in 5 patients they did not agree. In 41 of 98.. View More»
  DOI: 10.4172/2329-6917.1000127

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