School of Pharmaceutical Sciences,
São Paulo, Brazil and Department of Pathology, Emory University School of Medicine, Atlanta-30322, Georgia
Can Proteins Use Electricity for Signaling One Another?
Author(s): Fonseca SL and Nakaya HIFonseca SL and Nakaya HI
Base excision repair is of paramount importance in maintaining integrity of bacteria as well human genomes against chemical and oxidative damage. The enzymatic activity of the proteins involved in this process is well characterized. More obscure, though, is how DNA repair proteins effectively scan the genome in order to find these lesions. Scanning the genome by simply sliding through the double helix, or through random diffusion, takes up to 100 times longer than DNA repair proteins actually take to detect the lesions. For example, only 30 copies of DNA-repair protein MutY are usually found in an E. coli cell. If these 30 proteins slide through the 5 million base pairs of E. coli genome at 200 bps-1, it would take more than 13 min to scan the genome entirely. This is not compatible to an organism that can replicate every 30 minutes. Similarly, transcriptional regulators are able to f.. Read More»