Journal of Drug Metabolism & Toxicology
Open Access
ISSN: 2157-7609
+44-20-4587-4809
ISSN: 2157-7609
+44-20-4587-4809
Mostafa Ibrahim ElAwady
Clinical Pharmacy Department, Hamad Medical Corporation, Rumailah Hospital,
Doha
Qatar
Case Report
Phenytoin Delayed Excretion because of Esomeprazole Co-administration
Author(s): Mostafa Ibrahim ElAwady, Mahmoud Refaee, Mohamed Sherbash, Hanadi Al Hamad and Ameena AlYazeediMostafa Ibrahim ElAwady, Mahmoud Refaee, Mohamed Sherbash, Hanadi Al Hamad and Ameena AlYazeedi
Background: Drug Interaction between Phenytoin and Esomeprazole is not commonly reported or widely recognized. A case of Phenytoin toxicity post prolonged administration of phenytoin and esomeprazole is reported.
Case Summary: A 22 years old female diagnosed with MELAS (Mitochondrial myopathy, Encephalopathy, Lactic Acidosis, stroke like symptoms). She was maintained on Phenytoin 100 mg suspension via nasogastric tube every 8 hours as anticonvulsant for 3 years and esomeprazole 40 mg via nasogastric tube every 24 hours for hyperacidity. After 7 months from co-administration of phenytoin and esomeprazole the patient developed bradycardia, hypotension with nystagmus so upon checking the phenytoin trough serum level it was found to be 163 μmole/L, phenytoin was suspended and serum level monitored daily but it was found to be increasing to 167 &.. View More»
DOI:
10.4172/2157-7609.1000231