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Journal of Drug Metabolism & Toxicology

Journal of Drug Metabolism & Toxicology
Open Access

ISSN: 2157-7609

Merle G. Paule

Merle G. Paule

Director National Center for Toxicological Research U.S. Food & Drug Administration USA

Biography
 Currently he is working as an Director at Division of Neurotoxicology, Behavioral Toxicology Laboratory and Senior Biomedical Research Scientist Completed his graduation and post-graduation at University of California, Davis School of Medicine – PhD, Pharmacology and Toxicology (1983) University of California, Davis – BS, Biochemistry (1976), Staff Fellow, Division of Teratogenesis Research, National Center for Toxicological Research (1983-1986) Post Doctoral Fellow, Department of Pharmacology and Interdisciplinary Toxicology, University of Arkansas for Medical Sciences (1982-1983)
Research Interest

As the FDA’s Director of the Division of Neurotoxicology at the National Center for Toxicological Research (NCTR), Dr. Paule leads research focused on identifying approaches and methods for assessing the neurotoxicity of known or suspected neuroactive chemicals responsible for inducing brain-related disorders. His division facilitates FDA chemical evaluation and regulation, elucidating neurotoxic effects of therapeutic drugs, food additives and products, and other chemical substances. The ultimate goal of this research is to determine ideal dosage levels or conditions at which these chemicals can be used most effectively with minimal adverse side effects, securing the safety of the consumer. Dr. Paule’s division employs multidisciplinary approaches to develop quantitative biomarkers and identify biological pathways associated with neurotoxicity, permitting opportunities for improved risk assessment and the development of novel therapeutics. Currently, Dr. Paule is conducting research projects directly related to SmartTots, including animal-based studies regarding the potential effects of anesthetics on the developing brain. His research in rodents and non-human primates has been instrumental in alerting the medical and scientific communities of the potential neurotoxic properties of commonly used anesthetics and sedatives. Dr. Paule’s direct experience with anesthetic-induced neurotoxicity is a significant asset to the SmartTots Scientific Advisory Board. 

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