Journal of Drug Metabolism & Toxicology
Open Access
ISSN: 2157-7609
+44-20-4587-4809
ISSN: 2157-7609
+44-20-4587-4809
Masaki Otagiri
Faculty of Pharmaceutical Sciences,
4-22-1 Ikeda, Kumamoto 862-0082
Japan
Research Article
A Fourteen-Day Observation and Pharmacokinetic Evaluation after a Massive Intravenous Infusion of Hemoglobin-Vesicles (Artificial Oxygen Carriers) in Cynomolgus Monkeys
Author(s): Kazuaki Taguchi, Hiroshi Watanabe, Hiromi Sakai, Hirohisa Horinouchi, Koichi Kobayashi, Toru Maruyama and Masaki OtagiriKazuaki Taguchi, Hiroshi Watanabe, Hiromi Sakai, Hirohisa Horinouchi, Koichi Kobayashi, Toru Maruyama and Masaki Otagiri
Hemoglobin-vesicles (HbV) are a cellular type hemoglobin-based oxygen carrier in which a concentrated hemoglobin solution is encapsulated within a phospholipid vesicle (liposome). Although it was previously revealed that HbV possesses a higher biocompatibility, low toxicity and no accumulation in the body in an animal model, these assessments were limited to the use of rodents, including mice, rats and rabbits as models. The aim of this study was to observe the effects of the administration of HbV in a nonhuman primate. For this purpose, cynomolgus monkeys were used as the model and the systematic response, serum biochemical analysis and pharmacokinetic properties were monitored for 14 days after a massive intravenous injection of HbV at a putative dose (1400 mg Hb/ kg, 17.5 mL/kg). All of the monkeys tolerated the massive amount of injected HbV and survived, and no a.. View More»
DOI:
10.4172/2157-7609.1000128