Journal of Leukemia
Open Access
ISSN: 2329-6917
+44 1300 500008
ISSN: 2329-6917
+44 1300 500008
Magdalena Czader
350 W.11th Street, Room 5034, Indianapolis, IN 46202-5200
Tanzania
Research Article
Changes in Antigen Expression in a Follow-up of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Author(s): Jiehao Zhou, Anupama Tewari, Mehdi Nassiri and Magdalena CzaderJiehao Zhou, Anupama Tewari, Mehdi Nassiri and Magdalena Czader
Objectives:Diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) depends on specific immunophenotype of select antigens and their characteristic density. However, reports detailing how the expression of specific antigen changes over time of disease course are sparse. Methods: We identified 37 CLL/SLL with initial and follow-up samples studied by flow cytometry. Expression levels of a panel of antigens were compared between initial and follow-up samples from the same patients. Results: There is a significant decrease in the CD23 density and in the percentage of CD23 positive cells, and a decrease in the density of CD5 in the follow-up samples. In contrast, a significant increase in the density of HLA-DR antigen was observed in the follow-up. Conclusion: The expression of selected antigen changes in the course of CLL/SLL. These alterations do not impact the diagnos.. View More»
DOI:
10.4172/2329-6917.1000177