Journal of Drug Metabolism & Toxicology
Open Access
ISSN: 2157-7609
+44-20-4587-4809
ISSN: 2157-7609
+44-20-4587-4809
Leming Shi
National Center for Toxicological Research,
3900 NCTR Road, Jefferson, AR 72079
Tanzania
Research Article
Sex Differences in the Expression of Drug-Metabolizing and Transporter Genes in Human Liver
Author(s): Lun Yang, Yan Li, Huixiao Hong, Ching-Wei Chang, Li-Wu Guo, Beverly Lyn-Cook, Leming Shi and Baitang NingLun Yang, Yan Li, Huixiao Hong, Ching-Wei Chang, Li-Wu Guo, Beverly Lyn-Cook, Leming Shi and Baitang Ning
Human sex differences in the gene expression of drug metabolizing enzymes and transporters (DMETs) introduce differences in drug absorption, distribution, metabolism and excretion, possibly affecting drug efficacy and adverse reactions. However, existing studies aimed at identifying dimorphic expression differences of DMET genes are limited by sample size and the number of genes profiled. Focusing on a list of 374 DMET genes, we analyzed a previously published gene expression data set consisting of human male (n=234) and female (n=193) liver samples, and identified 77 genes showing differential expression due to sex. To delineate the biological functionalities and regulatory mechanisms for the differentially expressed DMET genes, we conducted a co-expression network analysis. Moreover, clinical implications of sex differences in the expression of human hepatic DMETs are discussed. Thi.. View More»
DOI:
10.4172/2157-7609.1000119