Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Kuo-Chi Hung
People's Republic of China
Case Report
Unilateral Optic Nerve Leukemic Infiltration and Exudative Retinal Detachment as Initial Manifestations of Central Nervous System Relapse in Acute Lymphoblastic Leukemia of Children
Author(s): Kuo-Chi Hung and Hsi-Kung KuoKuo-Chi Hung and Hsi-Kung Kuo
Acute lymphoblastic Leukemia (ALL) is a malignant neoplasm caused by the proliferation of poorly differentiated precursors of the lymphoid cells, which are known as blast cells. It is primarily the most common type of childhood Leukemia. Although 70-80% with ALL is cured with modern chemotherapy, 20-30% still have to endure relapse, particularly in the central nervous system (CNS) after attainment of remission. Treatment to prevent recurrence is based on cranial irradiation and intrathecal chemotherapy after conventional induction chemotherapy and the achievement of complete remission. However, the orbital cavity and optic nerve are relatively unaffected by being shielded during brain irradiation and serve as sanctuaries of ALL. Here, we describe a 12-year-old boy with ALL for one year who achieved complete remission after induction chemotherapy. He developed sudden loss of ipsilatera.. View More»
DOI:
10.4172/2155-9570.1000359