Anesthesia & Clinical Research
Open Access
ISSN: 2155-6148
ISSN: 2155-6148
Khaled Yassen
Department of Anesthesia, Liver Institute,
Egypt
Research Article
Effect of Target-Controlled Infusion of Propofol-Fentanyl versus
Desflurane in Cirrhotic Patients Undergoing Major Hepatic Resection with
Transoesophageal Doppler Monitoring A Randomized Control Study
Author(s): Khaled Yassen, Amr Farouk Safty, Mohamed Hussien Abdullah, Ragab Saad Beltagy, Fatma Ahmed Mahmoud and Ahmed Mohamed AttarKhaled Yassen, Amr Farouk Safty, Mohamed Hussien Abdullah, Ragab Saad Beltagy, Fatma Ahmed Mahmoud and Ahmed Mohamed Attar
Background and aim: The choice of anaesthetic agents is important for cirrhotics undergoing liver resection. Aim is to compare Target Controlled Infusion (TCI) Propofol-Fentanyl versus Desflurane (Des) on recovery, hemodynamics monitored with Transoesophageal Doppler (TED), the effect on hepatocellular, kidney functions and economics. Patients and methods: Prospective randomized controlled study, 50 patients (Child A) divided equally. In (Des) group induction with fentanyl (1microgram/kg), propofol (2 mg/kg) and rocuronium (1 mg/kg) and maintenance with Desflurane. In (TCI) group the Propofol blood target concentration (Ct) for induction was set at 4 μg/min and Fentanyl infusion was set at 3 μg/kg for 30 seconds , 2 μg/kg/h for 30 min, 1.5 μg/kg/h from 31-150 min, and 1 μg/kg/h until 30 min before end. Both propofol and fentanyl maintained with Navigator pharmacokinetic.. View More»
DOI:
10.4172/2155-6148.1000485