Reproductive System & Sexual Disorders: Current Research
Open Access
ISSN: 2161-038X
+44 1300 500008
ISSN: 2161-038X
+44 1300 500008
Karin Hevner
Tanzania
Research Article
Differential Expression of HtrA1 and ADAM12 in Placentas from
Preeclamptic and Normotensive Pregnancies
Author(s): Daniel A. Enquobahrie, Karin Hevner, Chunfang Qiu, Dejene F. Abetew, Tanya K. Sorensen and Michelle A. WilliamsDaniel A. Enquobahrie, Karin Hevner, Chunfang Qiu, Dejene F. Abetew, Tanya K. Sorensen and Michelle A. Williams
Background: High temperature requirement factor A 1 (HtrA1) and A Disintegrin And Metalloproteinase 12 (ADAM12), which play roles in placental implantation and placental growth, have been implicated in the pathogenesis of preeclampsia.
Methods: We investigated relative mRNA expression of both genes in placental tissues from women with preeclampsia (N = 18) (average gestational age 36 weeks) and an equal number of women with normotensive pregnancies (average gestational age 39 weeks). Real-time polymerase chain reaction was used to measure mRNA extracted from term placental biopsies. Differential gene expression was evaluated using Student’s T-test and fold change analyses.
Results: Statistically significant increases in placental HtrA1 (1.69-fold, p = 0.030) and ADAM12 (1.48-fold, p =0.010) mRNA expression were o.. View More»
DOI:
10.4172/2161-038X.1000110