Reproductive System & Sexual Disorders: Current Research
Open Access
ISSN: 2161-038X
ISSN: 2161-038X
Kadir RE
Nigeria
Research Article
Testiculo-Protective Effect of Stem Bark Extract of Enantia chlorantha on Lead Induced Toxicity in Adult Wistar Rat (Rattus norvergicus)
Author(s): Oyewopo AO, Saalu LC, Dare BJ, Oyewopo CI, Jimoh AA, Yama OE, Kadir RE and Olaniyan OTOyewopo AO, Saalu LC, Dare BJ, Oyewopo CI, Jimoh AA, Yama OE, Kadir RE and Olaniyan OT
Background: The study was designed to investigate the effect of stem bark aqueous extract of Enantia chlorantha on the sperm parameters and the histo-architecture of the testis of adult Wistar rats treated with lead (IV) oxide. Methods: A total of 20 adult male rats weighing between 180 g-200 g were randomly selected into 4 groups (n=5). Group 1 was giving only phosphate buffered saline; Group 2 was treated with 150 mg/kg body weight of the extract; Group 3 was treated with 300 mg/kg body weight of the extract and destroying agent [lead (IV) oxide]; Group 4 was treated only with the destroying agent [lead (IV) oxide] orally once daily for 14days of experimental period respectively. Animals were sacrificed by cervical dislocation 24 hours after the last administration of 14 days of experiment. Testis was dissected out following abdominal incision, fixe.. View More»
DOI:
10.4172/2161-038X.1000107