Autism-Open Access
Open Access

Juho Wedenoja

Publications

• Research Article
  Reelin Associated With Restricted and Stereotyped Behavior Based on Principal Component Analysis on Autism Diagnostic Interview-Revised
  Author(s): Ulrika Roine, Samuli Ripatti, Karola Rehnström, Timo Roine, Helena Kilpinen, Ida Surakka, Juho Wedenoja, Tero Ylisaukko-oja, Elli Kempas, Jaana Wessman, Irma Moilanen, Marja-Leena Mattila, Marko Kielinen, Katja Jussila, Saara Suomalainen, Esko Pulkkinen, Lennart von Wendt and Leena PeltonenUlrika Roine, Samuli Ripatti, Karola Rehnström, Timo Roine, Helena Kilpinen, Ida Surakka, Juho Wedenoja, Tero Ylisaukko-oja, Elli Kempas, Jaana Wessman, Irma Moilanen, Marja-Leena Mattila, Marko Kielinen, Katja Jussila, Saara Suomalainen, Esko Pulkkinen, Lennart von Wendt and Leena Peltonen
  
  Background: Twin and family studies have indicated a strong genetic component in autism spectrum disorders, and genetic studies have revealed highly heterogeneous risk factors. The range and severity of the symptom presentation also vary in the spectrum. Thus, symptom-based phenotypes are putatively more closely related to the underlying biology of autism than the end-state diagnosis. Methods: We performed principal component analysis on Autism Diagnostic Interview-Revised algorithm for 117 Finnish families and 594 families from the Autism Genetic Research Exchange (AGRE). The resulting continuous component scores were used as quantitative phenotypes in family-based association analysis. In addition, K-means clustering was performed to cluster and visualize the results of the PCA. Unaffected siblings were included in the study. .. View More»
  DOI: 10.4172/2165-7890.1000107

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